Liposomes (50-1000nm) are the part of a specific type of drug delivery system which is non-toxic and biodegradable in nature. That having ability to reduce the toxicity also enhances the therapeutic efficiency and protects the drug which is encapsulated, from the degradation and immediate dilution. These can be prepared by using various techniques like lipid hydration method, sonication method and solvent injecting method etc. But the selection of technique is depended upon the size of liposome which we want. The main disadvantage of this dosage form is it is very much costly and also having time consuming process. But it has major applications in the form of extrusion for homogeneous size, long circulating liposomes, triggered release liposome, remote drug loading, ligand targeted liposomes and containing combination of drugs. These applications are helpful for advanced drug delivery of anticancer, antifungal and anti-inflammatory drug, the delivery of gene medicine, delivery of anaesthetic and antibiotic drug. The newer researches in this field include hybrid liposomes, phototrigerable liposomes which are fabricated to have the improved functionality. These serves as the upcoming novel nanomedicinal chemotherapy technique.

:Objective: The purpose of this study was to prepare Eudragit S-100 coated salbutamol sulphate matrix tablet for chronotherapeutic drug delivery system for the treatment of nocturnal asthma. Methods and Material:This study is designed to analyze the effect of Eudragit S-100 coating on the drug release from hydroxypropyl methylcellulose matrix to achieve the time and pH dependent chronotherapeutic drug delivery system of salbutamol sulphate. Hydroxypropyl methylcellulose matrix tablets of salbutamol sulphate were prepared by wet granulation method and coated with Eudragit S-100 using dip coating method. Then the tablets were evaluated for different physical parameters, compatibility studies and in vitro dissolution. Results: Matrix tablets of salbutamol sulphate have been characterized for weight variation, hardness, friability and drug content. HPMC matrix tablet failed to control the drug release in initial hrs. and shows 68 ± 0.71% of the drug release. Formulation FMS 5 (HPMC K-100) selected for coating with Eudragit S-100 as it shows significant drug content uniformity and consistent drug release. Eudragit S-100 coated formulations control the drug release in first hrs. at pH 1.2 and 6.8 and shows burst release at pH 7.4 after 7 hrs. This is due to pH dependent nature of eudragit polymer. Compatibility studies revealed that there was no interaction between drug and the polymers. Conclusion: From observations mentioned in the results, it is obvious that the developed salbutamol sulphate enteric coated matrix tablets are suitable for chronotherapeutic drug delivery system.

Objective: The aim of the study was to develop a precise, accurate, and rapid ultraviolet spectrophotometric method for simultaneous estimation of levosulpiride (LEVO) and rabeprazole sodium (RBS) in the binary mixture and to validate the method as per ICH guidelines.Method: Estimation of LEVO and RBS was performed by Q-absorbance method. Analysis was performed using the ratio of absorbance at two selected wavelengths, one at iso-absorptive point and other is the absorbance maxima of any one of the components. Single scan spectrum and the overlain spectrum conclude that absorbance maxima of LEVO and RBS are 228 and 291.8 nm, respectively, with a coinciding iso-absorptive point at 255 nm. Method uses a ratio of absorbance for assay at 255 and the second wavelength is 291.8 nm, λ max for RBS. It is also applicable at 228 nm, as the second wavelength.Results: Linearity of LEVO and RBS was found to be 25-125 and 4-36 μg/ml, respectively. The accuracy of the LEVO and RBS was found 99.26% and 99.51%, respectively and Sandell's sensitivity ranged between 0.0238 and 0.594 µg/cm 2 . Assay of LEVO (75 mg) and RBS (20 mg) in capsule dosage form was found 99.5% and 98.69% w/w, respectively. Conclusions:The developed method for the estimation of LEVO and RBS in binary mixture were found to be simple, accurate, robust, and reproducible. No interference of excipients and the degraded product was found during the estimation. Therefore, the method can be successfully applied for routine quality control analysis.

Chewing gum is a highly convenient and controlled release transbuccal drug delivery system taken without water. It is gaining popularity as a selfadministrable carrier for the medication used for motion sickness, smoke cessation, hypertension, xerostomia, dental caries, pain, as nutritive and energy supplements. Functional chewing gum favors both local and systemic effects intended to be chewed about half an hour. It has emerged out with a fast onset of action either by direct absorption or swallowed with saliva into gastrointestinal tract.It has better bioavailability that lowers the doses and reduces the gastric side-effects. Gums adhere with ease and compliance of administration to children and dysphagia patients. Chewing gums are formulated using a water-insoluble gum base with water-soluble excipients with the active ingredient in the case of medicated gums. European Pharmacopeia standards used for release studies, there are no other particular official standards. It has attracted the researchers as successful potential drug delivery system in coming future. The present article reviews it as novel drug delivery system including its merits and limitations, material and methods of formulation and evaluation.