Aim::
To formulate and preliminary evaluated polysaccharide based mucoadhesive floating tablets of Cinnarizine.
Background::
Gastro-retentive drug delivery systems has proved to be a successful approach to enhance the gastric residence
with site specific targeting for achieving local or generalized effect. Various patents has also been filed globally employing
gastro-retentive approach.
Objective::
The study is designed to explore the mucoadhesive and low density characteristics of corn fibre gum (CFG) for
preparation of gastro-retentive floating tablets of cinnarizine.
Methods::
Floating tablets were prepared by direct compression technique using different concentrations of CFG (45, 50,
60% w/w). The formulated floating tablet batches were evaluated for their hardness, friability, drug content, floating
duration/ lag time, swelling behavior, bioadhesive strength and in vitro drug release.
Results::
Mucoadhesive strength was found to increase with an increment in the polysaccharide concentration. Swelling
index was found to increase both with the increase in CFG concentration and with duration for which tablet remains in
medium. The in vitro drug release studies indicated decrease in drug release (91% to 77%) with the increase in polymer
concentration. The release data was further fitted to various kinetic models which revealed the drug release to be in
accordance with Zero-order and Higuchi models, indicating polymer to exhibit the swellable matrix forming abilities. The
value of n (between 0.458 and 0.997) from Korsemeyer Peppas model depicted the possibility of drug to follow more than
one mechanism of release from the formulation i.e. diffusion and erosion. Stability studies revealed the preparations to
retain their integrity and pharmaceutical characteristics at variable storage conditions.
Conclusion::
Thus from the research findings, CFG could be concluded to possess potential binder, release retardant and
mucoadhesive characteristics which could be successfully employed for the formulation of gastro-retentive floating tablets.
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