QbD based synthesis and characterization of polyacrylamide grafted corn fibre gum

Singh, Akashdeep; Mangla, Bhumika; Sethi, Sheshank; Kamboj, Sunil; Sharma, Radhika; Rana, Vikas

doi:10.1016/j.carbpol.2016.08.089

Cited by 20 publications

(5 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This issue can be avoided by incorporating ZLP into a mucoadhesive disk for buccal delivery. Therefore, buccal delivery has always been an attractive option because it bypasses the devastating metabolism associated with other conventional oral routes, resulting in increased bioavailability (Singh et al, 2017). Extending the half-life of drugs with a short half-life reduces frequent dosing and, in this study, prevents early morning awakening without middle-of-the-night dosing.…”

Section: Introductionmentioning

confidence: 86%

“…An optimized method was used to calculate the swelling index (Koirala et al, 2021). The grafted gum shows a marginally higher SP in phosphate buffer (pH 6.8) compared with pure Moringa gum (Kumar and Rai, 2012;Singh et al, 2017).…”

Section: Swelling Indexmentioning

confidence: 92%

“…Later, an excess of acetone (30% v/v) was poured into the gel-like mass in the reaction vessel (Duan et al, 2019). The graft copolymer precipitate was collected, dried at 40°C, pulverized, and sieved with a #100 sieve (Kokilambigai et al, 2017;Shi et al, 2019;Singh et al, 2017). This was followed by purification (Panda, 2014).…”

Section: Modification Of Moringa Gum By the Grafting Techniquementioning

confidence: 99%

“…The BD, TD, AR, HR, and Carr's index of pure gum as well as modified Moringa gum are shown in Table 2. Dried gum powder shows excellent flow properties and compressibility, making them suitable for direct compression tableting (Singh et al, 2017).…”

Section: Powder Flow Propertiesmentioning

confidence: 99%

See 3 more Smart Citations

Formulation and characterization of zaleplon buccal disks using grafted Moringa oleifera gum

Dhiman¹,

Bhatt²,

Mannan³

et al. 2022

J App Pharm Sci

View full text Add to dashboard Cite

Natural modified gums act as drug release modifiers in novel drug delivery systems. These modified gums help to alter the physicochemical properties of the drugs. Zaleplon (ZLP) is a pyrazolopyrimidine that is used to treat insomnia. It has a significant problem from a pharmaceutical point of view that it undergoes extensive first-pass hepatic metabolism due to which it has a very short elimination half-life which leads to low bioavailability. The present investigation aimed to study the suitability of grafted Moringa oleifera gum as a mucoadhesive polymer in the formulation of ZLP buccal disks that would allow for pulsatile release via the buccal route, while avoiding extensive hepatic metabolism, increasing bioavailability, and avoiding early morning awakening. The modified M. oleifera gum was prepared using a microwave-assisted graft copolymerization reaction. The optimal calculated concentrations of Moringa gum, ceric ammonium nitrate, and acrylamide were found to be 1.0, 0.1, and 5.0 g, respectively, yielding a graft copolymer with a 65% grafting efficiency. The graft copolymer was further characterized using Fourier transform infrared spectroscopy, X-ray diffraction, differential scanning calorimetry, and scanning electron microscopy. The total ash content, bulk density, angle of repose, Carr's compressibility index, tapped density, and Hausner's ratio of naive M. oleifera gum and graft copolymer were determined. The ZLP buccal disks incorporated with gum and graft copolymer were prepared and evaluated for parameters like mucoadhesive strength, mucoadhesive time, and swelling index. The characterization results indicated that the modified Moringa gum exhibited decreased crystallinity and increased surface smoothness. A comparison of buccal disks made of graft copolymer and naive gum revealed that the graft copolymer had a longer ex-vivo mucoadhesion time and a more significant controlled release effect.

show abstract

Section: Introductionmentioning

confidence: 86%

Section: Swelling Indexmentioning

confidence: 92%

Section: Modification Of Moringa Gum By the Grafting Techniquementioning

confidence: 99%

Section: Powder Flow Propertiesmentioning

confidence: 99%

See 2 more Smart Citations

Formulation and characterization of zaleplon buccal disks using grafted Moringa oleifera gum

Dhiman¹,

Bhatt²,

Mannan³

et al. 2022

J App Pharm Sci

View full text Add to dashboard Cite

show abstract

“…Quality by Design (QbD) is an approach for creating and manufacturing products. QbD’s reliability is proved via a new scalable synthetic technique that meets purity and efficacy goals for the completed methimazole product. − To fulfill QbD goals, one must understand the procedure, its factors, and their performance envelope. To verify QbD’s robustness, critical process parameters (CPPs) were explored.…”

Section: Introductionmentioning

confidence: 99%

Scalable Process of Methimazole

Goura

Babu

Katari

et al. 2022

Org. Process Res. Dev.

View full text Add to dashboard Cite

Base hydrolysis of imidazole carboxylate was observed to be an efficient route for the scalable synthesis of the antithyroid drug methimazole. Ethyl 3-methyl-2-thioxo-2,3-dihydro-1H-imidazole-1-carboxylate ( 12) was produced as a key intermediate in the reaction of 1-methyl-1H-imidazole (4) with ethyl chloroformate (11) and sulfur. Compound 12 undergoes hydrolysis in two steps in the presence of a base to give methimazole (1) with an overall yield of 78%. The process was studied through the Quality by Design (QbD) concept and observed to be robust.

show abstract

Carnauba (Copernicia prunifera) palm tree biomass as adsorbent for Pb(II) and Cd(II) from water medium

Oliveira

Abreu

Romão

et al. 2020

Environ Sci Pollut Res

View full text Add to dashboard Cite

QbD based synthesis and characterization of polyacrylamide grafted corn fibre gum

Cited by 20 publications

References 30 publications

Formulation and characterization of zaleplon buccal disks using grafted Moringa oleifera gum

Formulation and characterization of zaleplon buccal disks using grafted Moringa oleifera gum

Scalable Process of Methimazole

Carnauba (Copernicia prunifera) palm tree biomass as adsorbent for Pb(II) and Cd(II) from water medium

Contact Info

Product

Resources

About