Propionibacterium acnes are gram-positive anaerobic microorganism, which have been most recognized as a key factor for the development of acne. Acne is the most common skin disease and Propionibacterium acnes have been recognized as pus-forming bacteria triggering an inflammation in acne. Acne vulgaris is a chronic inflammatory disease of the pilosebaceous follicle, characterized by comedones, papules, pustules, cysts, nodules and often scars in certain sites of predilection, namely, the face, neck, upper trunk and arms. The present compiled work was conducted to make an overview and correlation between antimicrobial activities of medicinal plants against these etiologic agents of acne vulgaris. Different parts of various medicinal plants belongs to families like Liliaceae, Rutaceae, Zingiberaceae, Myrtaceae, Lamiaceae, etc. contains alkaloids, tannins, flavonoids, terpenoids, volatile oil and essential oil which are reported with significant effect against this bacteria.
The anti ulcerogenic activity of Sesbania graindiflora was evaluated by employing aspirin and pylorus ligation induced ulcerations in rats. Non-steroidal anti-inflammatory drugs (NSAIDs) like aspirin are known to induce gastric ulceration. The reason being attributed principally to inhibition of biosynthesis of 'cytoprotective prostaglandins' (by inhibition of cyclo-oxygenase pathway of arachidonic acid metabolism), resulting in overproduction of leukotrienes and other products of 5-lipoxygenase pathway .Hence, the protective action of Sesbania graindiflora against aspirin-induced gastric lesions could possibly be due to its 5-lipoxygenase inhibitory effect.
Out of the most common uses for image processing is face identification, which is important in the technological field. Recognizing faces is a hot issue for verification, especially in student attendance competitions. A face recognition attendance system uses high-definition surveillance and other computer technologies to identify students using face biostatistics. The developing system aims to digitize the outdated method of calling names and maintaining pen-and-paper attendance records. The existing procedures for recording attendance are cumbersome and time-consuming. Manual recording allows for easy manipulation of maintenance records. Traditional attendance systems and current biometric technologies are subject to proxies. As a result, this study is proposed to address all of these issues.
The goal of this study was to develop a parenteral microemulsion formulation of Ceftazidime antibiotics. The ceftazidime sparingly soluble in organic solvent like ethanol, DMSO, and dimethyl formamide were determined. For biological experiment, organic solvent- free aqueous solutions of ceftazidime (hydrate) are prepared by directly dissolving the crystalline compound in aqueous buffer. The peudo ternary phase diagrams of oil, surfactant, cosurfactants (Butanol/ Isopropyl alcohol mixture) and water were constructed to identify boundaries for microemulsion existence. Ceftazidime microemulsion particle size, solution viscosity and conductivity were evaluated. The microemulsion stability and haemolytic activity were examined after dilution in 5% dextrose solution for injection to 1 mg/mL ceftazidime. In vitro haemolysis studies indicated that Ceftazidime microemulsions were well tolerated by erythrocytes. The novel microemulsion formulation of Ceftazidime was developed that is suitable for parenteral administration. This new formulation could potentially have less vehicle-associated side effects that current commercial formulation of Ceftazidime based on Cremophor® EL and isopropyl alcohol solution.
Objective: To investigate the antidiabetic effect of aqueous extract of Chlorophytum borivilianum (safed musli) root. Methods: The collected roots were washed; shade dried and was pulverized with a mechanical pulverizer for the size reduction. It was then passed through mesh of size # 60 and the fine powder was collected and was used for the experiment for powder microscopy and preparation of extract. The root powder (1000 g) was subjected to cold maceration in 2 L of sterile distilled water for 48 hours at room temperature, filtered into a clean round bottom flask. The α-Glucosidase inhibitory activity was conducted where 100µl of a sample of different concentrations was incubated with 50µl α-glucosidase (1.0 U/ml) (from Saccharomyces cerevisiae) in phosphate buffer (0.1 M, pH 6.8) for 10 min at 37°C. The reaction was initiated by addition of 50 µl of substrate: 5 mM, p-nitrophenyl-α-D glucopyranoside in a 0.1 M phosphate buffer at pH 6.8. P-nitrophenol's release kinetics. The α-Amylase Inhibition where 250µL of the extract (5mg/mL) was preincubated with 250µL of-amylase solution for 10min at 25°C in one set of tubes. In another set of tubesamylase was preincubated with 250µL of phosphate buffer (pH 6.9). 250µL of starch solution at increasing concentrations (0.30-5.0mg/mL) was added to both sets of reaction mixtures to start the reaction. The mixture was then incubated for 10min at 25°C and then boiled for 5min after the addition of 500µL of DNS to stop the reaction. Results: In this study acarbose was also used as a standard drug for α-glucosidase inhibitor. Acarbose at a concentration of (100-1000 µg/ml) showed αglucosidase inhibitory activity from 30. 31±0.1084to 84.05±0.2075% with an IC value 411.436567µg dry extract, & acarbose was also used as a standard drug for α amylase inhibitor. Acarbose at a concentration of (100-1000 µg/ml) showed α-glucosidase inhibitory activity from 23.33±0.1415 to 62.05±0.2725% with an IC value 236.774194µg dry extract. Conclusions: As a result, we found that the extract of C. boriviliamum have free radical scavenging activity and inhibitory activity against α-amylase and α-glucosidase and this therapeutic potentiality could be exploited in the management of post prandial hyperglycemia in the treatment of type 2 diabetes mellitus.
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