Central venous access is one of the most common surgery procedures worldwide, especially in pediatric surgery. Local and regional complications as the result of venous catheter permanence time are frequently described as: thrombosis, infection, edema and local cellulite, movement and loss of the catheter. Other severe complications such as endocardiac and hemorrhagic lesions are also described and considered the cause of catheter early removal. In the literature few studies have addressed vascular and perivascular lesions and complications as the result of central venous access to peripheral veins, given the difficulty of setting up venous catheterization experimental models to study blood vessels and perivascular tissue alterations after catheterization. In the present venous catheterization experimental model, rabbits were divided into two groups based on the time that the venous catheters were maintained in their veins. Group a composed of 7 New Zealand male rabbits was submitted to a 15-day treatment; and the 6 New Zealand male rabbits of group B were treated during 90 days. Both groups presented similar inflammatory conditions since there was no significant difference between groups. Therefore, the results may well suggest that the endothelial inflammatory reaction could have developed at an early initial short period and by maintaining the catheter, the inflammatory reactions would have decreased or disappeared. Aimed at studying these vascular and perivascular alterations in venous catheterization, the present study proposes an experimental rabbit model that allows the analysis of differences in local vascular and perivascular histological variations and compares histological differences be-* Corresponding author. B. R. Rodrigues et al. 533tween both venous catheterization groups each of them with different periods of treatment.

O adenocarcinoma colorretal é uma neoplasia muito frequente, originando metástases para diversos órgãos do corpo. Seus sintomas envolvem o sistema digestivo e podem variar. A doença tem uma evolução rápida, tornando o prognóstico mais reservado para casos com diagnóstico tardio. Uma disseminação metastática rara desse tipo de câncer é a região endotraqueal, apresentamos o relato de uma paciente de 46 anos, com história de adenocarcinoma colorretal T 3 N 1 M1, submetida a retossigmoidectomia, quimioterapia e radioterapia neoadjuvantes. Com evolução, em 3 anos, de metástase pulmonar tratada com segmentectomia pulmonar e lobectomia inferior direita. Após um ano da operação, ainda em quimioterapia, desenvolveu metástase endotraqueal confirmada por estudo anatomopatológico e imunohistoquímica.Descritores: Neoplasias da traqueia, Adenocarcinoma, Neoplasias colorretais, Metástase neoplásica

3172 Platelets have a predominant role in the pathogenesis of Acute Coronary Syndromes (ACS). It is believed that the mean platelet size, evaluated by the mean platelet volume (MPV), is a sensitive indicator of platelet reactivity and thrombogenicity potential. Many studies found association between the MPV and the ACS or the occurrence of Acute Myocardial Infarction (AMI). The reasons for this are not well known, but may be due to platelet aggregation or consumption. The aim of this study was to evaluate the MPV in Coronary diseases patients and correlate it with risk factors to these diseases. The patients included were those who would be submitted to procedures like coronariography, angioplasty and myocardial bypass. They were evaluated by a hemogram with the MPV and answered to a questionary about risk factors to coronary disease. We observed that all patients (N=72) had an elevated MPV, ranging from 9.1 to 13,7 and a mean of 11,57fL. The mean age was 63,4 years, being 32% women and 68% men. The mean MPV in the female group was slightly higher than in the men group (11,95 fL vs 11,39), but not statistically significant.(p=0,09) The relation between risk factors and the MPV was as follows: High Corporeal Mass Index had a higher mean MPV (11,63 vs 11,46fl), but no statistically significance was found.(p=0,24) When asked about Hypertension, Diabetes and Dislipidemia, 88,9% confirmed at least one of these diseases, and had a mean MPV higher than those without them. (11,6vs11,3fl) (p<0,0001) When each group, with one of these diseases were compared with the group without them, we observed that the group with diabetes had a higher MPV (11,46 vs 11,30fl)(p=0,01), the same happening with the hypertension group (11,60 vs 11,30fl)(p<0,0001), and in the group of dislipidemic patients, in whom we observed the higher mean value (12,3 vs 11,30 fl)(p=0,019) We could not find differences between the MPV of smokers and no smokers (11,60 vs 11,63 fL)(p=0,9080). The history of previous Myocardial Infarction did not correlate with a higher MPV (11,56 vs 11,61fl)(p=0,41) The family history of coronary diseases did correlate with a higher mean MPV. (11,61vs11,46)(p=0,0201). At last, the use o one anti-aggregating agent was associated with a lower MPV (11,57vs11,59)(p=0,0012). It was expected that all patients had an elevated MPV, and this is observed in some publications. The explanation for these results is linked to the fact that all patients in the study had coronary arterial diseases and probably higher platelet consumption. This consumption stimulates the production of larger platelets, increasing the MPV. The risk factors are highly associated with coronary diseases and that is why they were associated with a higher mean MPV too. The MPV comes with a simple hemogram and is easily done, has no contra-indications, and with a very low cost can be used as a marker of coronary disease. Disclosures: No relevant conflicts of interest to declare.