Background: The metabolic syndrome is defined by the clustering of risk factors that predisposes people to diabetes and cardiovascular disease (CVD. MetS had a high (58%) prevalence of dyslipidemia, and increasing age, greater BMI, central obesity, hypertension, and high blood glucose levels have been found as independent predictors of dyslipidemia. Aim of the Work: This study aimed to role of lipid profile and fasting blood glucose in metabolic syndrome. Subjects and Methods: The research was carried out at the Index Medical College and Research Center in Indore, in the Department of Biochemistry. A total of 120 people with metabolic syndrome and 120 healthy controls were included in the study. A blood sample was taken from the anticubital vein and centrifuged to obtain serum, which was then evaluated for lipid profile and FBS levels quantitatively. Result and Conclusion: Present study suggested that the FBG is the most critical factor in MS, and all aspects of the lipid profile have significant relationships with MS. Keywords: Metabolic syndrome, fasting blood glucose

Objectives Preeclampsia is a multisystem illness that manifests in the third trimester of pregnancy after 20 weeks of gestation and is marked by proteinuria and hypertension (PE). Changes in lifestyle, such as eating a high-calorie diet and delaying delivery, have raised the likelihood of developing PE. Eclampsia, abrupt renal failure, thromboembolic episodes leading to cardiac and brain problems, pulmonary embolism, and coagulopathy associated with HELLP syndrome are a few of the complications that might follow preeclampsia in pregnant moms. The objects of this study is to estimate and correlate the levels of NGAL (neutrophil gelatinase associated lipocalin), IMA (ischemia modified albumin) and Uric acid in prreclampsia. Methods 40 diagnosed cases of preeclampsia and 40 healthy age and gestational age matched healthy controls were included in the study. Blood samples were collected from them and serum NGAL, IMA and Uric acid levels were estimated. Estimation of NGAL (neutrophil gelatinase associated lipocalin), IMA (ischemia modified albumin) was done by commercially available ELISA kits standard spectrophotometry methods in autoanalyzer Mind ray BS300 using commercially available kits. Results The parameters of NGAL and IMA were significantly increased in patients with PE (p<0.001) when compared with the healthy control subjects. γ-glutamyl transferases and OPN were found in patients with ALD (p<0.001) when compared with the control subjects. OPN showed significant positive correlations with AST (r=0.76, p<0.001), ALT (r=0.64 p<0.001), ALP (r=0.68, p<0.001), and GGT (r=0.61, p<0.001). Conclusions The current study focuses on the roles of NGAL and IMA, two sensitive markers of kidney injury that are particularly useful in identifying widespread endothelial dysfunction. As a result, the pattern of elevated NGAL and IMA levels can be useful for diagnosis.

The whole world is facing a highly challenging and extremely difficult task of facing a pandemic of coronavirus disease-2019 (COVID-19) caused by a very deadly and highly contagious virus named by WHO as severe acute respiratory syndrome coronavirus-2 (SARS CoV-2). This dangerous virus originated probably from bats and through undetermined intermediate hosts entered humans and first reported in seafood market of Hubei province of Wuhan, China in December 2019. Covid-19 spreads very fast by personal contact with patients and by micro droplets generated by sneezing and coughing by the patients. Covid-19 has infected more than 3.2 million people across the globe and claimed more than 229000 deaths to date (30/04/2020). The virus spreads faster than its two ancestors which are Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV) and Middle East Respiratory Syndrome Coronavirus (MERS-CoV), but has lower mortality then them. The spectrum of disease varies from asymptomatic to pneumonia, acute respiratory distress syndrome (ARDS) and multi organ dysfunction. The case fatality rate is estimated to range from 3 to 4%. Treatment is essentially supportive because of lack of definitive antiviral drugs or effective vaccine. As this disease is spreading across the continents very fast and due to lack of definitive treatment only way left is to prevent the infection is its containment. Prevention entails creating public awareness about this highly infectious disease, home isolation of suspected cases and those with mild illnesses and strict infection control measures at hospitals that include contact and droplet precautions. This review focuses on the genomic structure, viral replication and pathophysiology of SARS CoV-2 known till date as new studies are continuously shedding lights on the various aspects of this virus.

No abstract