Purpose: To study the epidemiological and anatomopathological aspects of urological cancers in Burkina Faso from 1988 to 2018. Patients and Methods: A cross-sectional, retrospective and descriptive study of histologically confirmed cancers that are collected from pathological anatomy laboratory records. The aspects studied were age, sex, location and histological type. Results: A total of 2204 cases of urological cancer were collected. The predominance was male with a sex-ratio of 9.6. The average age was 63.32 years. We found 1602 cases of prostate cancer (72.68%), 361 cancers of the bladder and excretory tract (16.4%), 180 cancers of the kidney (8.16%), 33 testis cancers (1.5%) and 28 penile cancers (1.3%). The predominant histological type of prostate cancer was adenocarcinoma (96.4%) with a Gleason score 7 in 30.4% of cases. Bladder cancer consisted of 50% epidermoid carcinomas. Kidney cancer was mostly nephrotoblastomas with 42.2% of cases. We noted 42.4% of seminomas among testis cancers and 89.3% of epidermoid carcinomas within penile cancers. Conclusion: The incidence of urological cancers is increasing in Burkina Faso. These cancers occur at a relatively advanced age with male predominance. Prostate cancers are at the forefront of these urological cancers. The establishment of a cancer registry would allow better follow up of cancers in our countries.

The treatment of urinary stones uses a varied therapeutic arsenal. Nowadays the mini-invasive techniques are the most used. We report our first experience on the results of flexible and semi-rigid ureteroscopy in the treatment of the upper urinary tract stones. Materials and Methods: A 20-month prospective study on flexible laser ureteroscopy was conducted at the Saint Camille Hospital of Ouagadougou. The inclusion criteria were for patients who had given informed consent and the presence of an unilateral obstructive upper urinary tract stone with an indication of surgical management. Results: 54 patients were treated with Holmium laser photo vaporization between January 2018 and August 2019. The average age of patients was 37.74 ± 17 years (11-83 years). The men were predominant at 55.56%, or a sex-ratio of 1.25. The average size of stones of 17.55 mm ± 4.16 mm (11 mm to 25 mm) with pyelic, ureteral and calyceal localization in respectively 42.6%, 33.3% and 24.1% of cases. The average duration of the interventions was 77.92 ± 43.57 minutes (11 to 180 minutes). We used drainage in 90.91% of the cases. The average duration of hospitalization was 1.2 ± 0.73 days with extremes ranging from one day to 6 days. The vaporization without residual fragment which is a success was 78.46%. Conclusion: Laser ureteroscopy is a newly used method at the Saint Camille hospital. The achievement of good results and its low morbidity encourage us to promote its extension and its use in sub-Saharan African hospitals.

Purpose: To conduct a study of epidemiological, diagnostic and therapeutic aspects of urethral strictures at Yalgado Ouedraogo University Teaching Hospital. Patients and methods: It was about a retrospective and descriptive study conducted in the urology division of Yalgado Ouedraogo Hospital from October 1 st 2009 to September 30 th 2014. All the patients, included in this study, had a urethral stricture confirmed by the voiding retrograde cystourethrogram (VCUG) or during surgical intervention with useful surgical report and medical file. Results: During the period of study, 127 complete medical records were found. The hospital prevalence was 10.1%. The average age of the patients was 50.5 (from 3 to 80 years). 55.6% of the patients were from rural areas. Dysuria and urinary retention were the major causes of consultation with respectively 66.7% and 33.3%. The aetiology of urethral stricture was infectious in 71.4% of the cases. The VCUG permitted to objectify the characteristics of the stenosis. The urethral stenoses were single in the majority of the cases, about 88.8% of cases. The bulbar urethral stricture was the major location. Escherichia coli was isolated in 77.7% of the urinary infections. The majority of patients (61.9%) had undergone open surgery including 39.7% end to end anastomosis. No endoscopic treatment was recorded. Conclusion: The urethral stenosis is frequent in our division. Its major aetiology is infectious. The treatment is dominated by open surgery in our context.

Background Prostate cancer (Pca) is a public health problem that affects men, usually of middle age or older. It is the second most common cancer diagnosed in men and the fifth leading cause of death. The RNASEL gene located in 1q25 and identified as a susceptibility gene to hereditary prostate cancer, has never been studied in relation to prostate cancer in Burkina Faso. The aim of this study was to analyze the carriage of RNASEL R462Q and D541E mutations and risks factors in patients with prostate cancer in the Burkina Faso. Methods This case-control study included of 38 histologically diagnosed prostate cancer cases and 53 controls (cases without prostate abnormalities). Real-time PCR genotyping of R462Q and D541E variants using the TaqMan® allelic discrimination technique was used. Correlations between different genotypes and combined genotypes were investigated. Results The R462Q variant was present in 5.3% of cases and 7.5% of controls. The D541E variant was present in 50.0% of cases and 35% of controls. There is no association between R462Q variants (OR= 0.60; 95%IC, 0.10 - 3.51; p= 0.686) and D541E variants (OR=2.46; 95%IC, 0.78 - 7.80; p= 0.121) and genotypes combined with prostate cancer. However, there is a statistically significant difference in the distribution of cases according to the PSA rate at diagnosis (p ˂ 0.001). For the Gleason score distribution, only 13.2% of cases have a Gleason score greater than 7. There is a statistically significant difference in the Gleason score distribution of cases (p ˂ 0.001) Conclusions These variants, considered in isolation or in combination, are not associated with the risk of prostate cancer.

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