Background: Dyslipidemia is the risk factor of cardiovascular diseases (CVD) such as coronary heart diseases (CHD) and artherosclerosis. Dyslipidemia is a lipid metabolism disorder, one of it is a decreased High Density Lipoprotein (HDL) cholesterol level in the blood. Flaxseed and sesame oil contained linolenic acid, linoleic acid and antioxidant have potential effect in increasing HDL cholesterol level in the blood. Objective: Investigate the effect of flaxseed and sesame oil combination administration on HDL cholesterol level in dyslipidemia Sprague dawley rats. Methods: A true experimental with pre-post randomized control group design on 24 dyslipidemia Sprague dawley rats which was randomized into 4 groups. The control group was given standard diet and high cholesterol diet and three treatment groups were given high cholesterol diet also flaxseed and sesame oil in combination with the dose of 1ml/200 gr body weight (P1), 2 ml/200 gr body weight (P2), and 3 ml/200 gr body weight (P3) for 14 days. High Density Lipoprotein (HDL) cholesterol level was analyzed by CHOD-PAP method. Datas were analyzed by Paired t-test and Anova. Results: There was a significant difference on HDL cholesterol level before and after treatment in control group 1,43% (p=0,003). Treatment groups (P1,P2,P3) had significant elevation (p<0,05) on HDL cholesterol level respectively 18,49% (p=0,000), 29,21% (p=0,000), and 50,85% (p=0,000). Conclusion: Flaxseed and sesame oil combination for 14 days could increase HDL cholesterol level. The most potential effect in increasing HDL cholesterol level was shown in P2 the dose of 3 ml/200 gr body weight.
ABSTRAKLatar Belakang: Dislipidemia merupakan faktor risiko dari penyakit kardiovaskular (CVD) seperti penyakit jantung koroner (PJK) dan artherosklerosis. Dislipidemia adalah kelainan metabolisme lipid dalam darah. Salah satu kelainan komponen lipid yaitu menurunnya kadar kolesterol High Density Lipoprotein (HDL). Minyak rami dan minyak wijen yang mengandung asam linolenat, asam linoleat dan antioksidan yang berpotensi dalam meningkatkan kadar kolesterol HDL darah. Penelitian ini bertujuan untuk mengetahui pengaruh pemberian kombinasi minyak rami dengan minyak wijen terhadap kadar kolesterol HDL pada tikus dislipdemia. Metode : Penelitian true experimental dengan pre-post test randomized control group design terhadap 24 ekor tikus Sprague dawley dislipidemia dibagi secara acak menjadi 4 kelompok yaitu kelompok kontrol diberikan pakan standar dan tinggi kolesterol dan tiga kelompok perlakuan diberikan pakan tinggi kolesterol dan kombinasi minyak rami dengan minyak wijen dosis 1 ml/200 gBB, 2 ml/200 gBB, 3 ml/200 gBB selama 14 hari. Kadar kolesterol HDL diperiksa dengan metode CHOD-PAP. Data dianalisis dengan uji Paired t-test dan Anova. Hasil : Terdapat perbedaan penurunan kolesterol HDL secara bermakna sebelum dan sesudah perlakuan pada kelompok kontrol sebesar 1,43% (p=0,003). Kelompok P1, P2, P3 mengalami peningkatan kolesterol HDL secara bermakna (p<0,05) berturut-turut yaitu sebesar 18,49% ...
