The impact of winter atmospheric blocking over the Ural Mountains region (UB) coincident with different phases of the North Atlantic Oscillation (NAO) on the sea ice variability over the Barents and Kara Seas (BKS) in winter is investigated. It is found that the UB in conjunction with the positive phase of the NAO (NAO þ ) leads to the strongest sea ice decline. During this phase composites and trajectory analyses reveal an efficient moisture pathway to the BKS from the mid-latitude North Atlantic near the Gulf Stream Extension region where water vapor is abundant due to high sea surface temperatures. The NAO þ -UB combination is an optimal circulation pattern that significantly increases the BKS water vapor that plays a major role in the BKS warming and sea ice reduction, while the increased sensible and latent heat fluxes play secondary roles. By contrast, much fewer dramatic impacts on the BKS are observed when the UB coincides with the neutral or negative phases of the NAO.Our results present new insights into the complex processes involved with Arctic sea ice reduction and warming. The mechanisms highlighted here potentially offer a perspective into the mechanisms behind Arctic multi-decadal climate variability.

Perfluorooctanoic acid (PFOA) is a ubiquitous environmental pollutant suspected of being an endocrine disruptor; however, mechanisms of male reproductive disorders induced by PFOA are poorly understood. In this study, male mice were exposed to 0, 0.31, 1.25, 5, and 20 mg PFOA/kg/day by oral gavage for 28 days. PFOA significantly damaged the seminiferous tubules and reduced testosterone and progesterone levels in the testis in a dose-dependent manner. Furthermore, PFOA exposure reduced sperm quality. We identified 93 differentially expressed proteins between the control and the 5 mg/kg/d PFOA treated mice using a quantitative proteomic approach. Among them, insulin like-factor 3 (INSL3) and cytochrome P450 cholesterol side-chain cleavage enzyme (CYP11A1) as Leydig-cell-specific markers were significantly decreased. We examined in detail the expression patterns of CYP11A1 and associated genes involved in steroidogenesis in the mouse testis. PFOA inhibited the mRNA and protein levels of CYP11A1 and the mRNA levels of 17β-hydroxysteroid dehydrogenase (17β-HSD) in a dose-dependent manner. Moreover, in vitro study showed the reduction in progesterone levels was accompanied by decreased expression of CYP11A1 in cAMP-stimulated mLTC-1 cells. Our findings indicate that PFOA exposure can impair male reproductive function, possibly by disturbing testosterone levels, and CPY11A1 may be a major steroidogenic enzyme targeted by PFOA.

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