Background and Objectives: Dysfunctional hypothalamus-pituitary-thyroid (HPT) axis have been documented in patients with depression. Condition of both excess and insufcient thyroid hormones can cause mood abnormalities including depression. Thyroid dysfunction is a common feature in depression, with mixed type of response. Unipolar and bipolar depressions are also related differently in consideration to thyroid status. This study comprises of assessment of the thyroid disorder prevalence in depressive patients and comparative analysis among unipolar and bipolar groups. Gender wise males were dominant with majority in bipolar group in the younge Result: r age group. Most of the cases were normal with few hyperthyroid and hypothyroid cases. Bipolar group comprised the majority of overt hyperthyroid, whereas unipolars were more in the subclinical hypothyroid category. This study concludes that differences exist in Conclusions: the thyroid response among the unipolar and bipolar depression group, more numbers of hypothyroidism in unipolar group