Monilethrix is a rare autosomal dominant hair shaft disorder with variable expressivity. It usually presents with short broken scalp hairs and follicular hyperkeratosis. Light microscopy of hair reveals a beaded appearance. Here, we report the case of a 32-year-old male who presented with sparse hair and follicular keratotic papules in the absence of any family history.
Probiotics are live microbial organisms that are beneficial to the host health when they are administered in adequate amounts. Since its introduction, the concept of probiotics has stimulated much interest and scientific research. Modulation of intestinal microbiota with probiotics is used as a therapeutic modality in many disease conditions. The role of probiotics in dermatological diseases like atopic dermatitis, acne, vaginal infections etc. is not yet established inspite of several studies on the same. As probiotics provide a safe and well-tolerated therapeutic modality in this era of antibiotic resistance and adverse effects, it becomes essential for us to validate the efficacy of its therapeutic supplementation. Herein, an attempt is made to review the current evidence from literature.
Paraganglioma-like dermal melanocytic tumor (PDMT) is a rare subtype of benign dermal melanocytic tumor, first described in 2004. Its histopathologic features resemble those of paraganglioma, showing presence of a distinctive partitioning of the tumor into small and large packets, nests, or short cords by delicate fibrous septa (zellballen pattern). But the immunostaining characteristics are those of melanocytic lesions, as PDMT express S-100, melan A, HMB 45 and lack pancytokeratin markers. It has a benign course, although a lesion of low malignant potential cannot be excluded. We describe a case of 60-year-old female who presented with three PDMT lesions on her right leg. To the best of our knowledge this is the first case reported from India.
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