Membrane fusion plays a lead role in the transport of vesicles, neurotransmission, mitochondrial dynamics, and viral infection. There are fusion proteins that catalyze and regulate the fusion. Interestingly, various types of fusion proteins are present in nature and they possess diverse mechanisms of action. We have highlighted the importance of the functional domains of intracellular heterotypic fusion, homotypic endoplasmic reticulum (ER), homotypic mitochondrial, and type-I viral fusion. During intracellular heterotypic fusion, the SNAREs and four-helix bundle formation are prevalent. Type-I viral fusion is controlled by the membrane destabilizing properties of fusion peptide and six-helix bundle formation. The ER/mitochondrial homotypic fusion is controlled by GTPase activity and the membrane destabilization properties of the amphipathic helix(s). Although the mechanism of action of these fusion proteins is diverse, they have some similarities. In all cases, the lipid composition of the membrane greatly affects membrane fusion. Next, examples of lipidation of the fusion proteins were discussed. We suggest that the fatty acyl hydrophobic tail not only acts as an anchor but may also modulate the energetics of membrane fusion intermediates. Lipidation is also important to design more effective peptide-based fusion inhibitors. Together, we have shown that membrane lipid composition and lipidation are important to modulate membrane fusion. Graphical Abstract

Quantum error detection has always been a fundamental challenge in a fault-tolerant quantum computer. Hence, it is of immense importance to detect and deal with arbitrary errors to efficiently perform quantum computation. Several error detection codes have been proposed and realised for lower number of qubit systems. Here we present an error detection code for a (2n + 1)-qubit entangled state using two syndrome qubits and simulate it on International Business Machines 16-qubit quantum computer for a 13-qubit entangled system. The code is able to detect an arbitrary quantum error in any one of the first 2n qubits of the (2n + 1)-qubit entangled state and detects any bit-flip error on the last qubit of the (2n + 1)-qubit entangled state via measurements on a pair of ancillary error syndrome qubits. The protocol presented here paves the way for designing error detection codes for the general higher number of entangled qubit systems.This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.