Introduction: Anti-tuberculosis drugs can cause adverse reactions including hepatitis and skin reactions. This case control study was aimed at fi nding out whether allergy to drug or food acts as a risk factor for the development of anti-tuberculosis drug induced hepatitis or skin reactions. Patients with tuberculosis on category 1 regimen, who presented to the Teaching Hospital Kandy Sri Lanka, due to anti-tuberculosis drug induced hepatitis or skin reactions from 1st July 2010 to 30th June 2011 were recruited. Methodology: Patients with drug induced hepatitis or skin reactions were grouped as cases and patients who didn’t develop hepatitis or skin reactions during the treatment period were selected as controls. Controls were matched for age, gender, weight, and consumption of alcohol. Cases and controls were inquired for the presence of allergy to drugs or food. Two groups were compared using odds ratio. Results: There were 61 cases [33 (54.1%) males, 28 (45.9%) females] and 61 controls .Ten patients (16.39%) among the cases had allergy to food or drugs while in control group only 2 (03.2%) had allergy. Odds ratio for the development of drug reactions in patients with a history of allergy was 5.8 (confi dence interval 1.2 to 27.6). Conclusion: Patients with allergy to drugs or foods have 5.8 times risk of developing anti-tuberculosis drug induced hepatitis or skin reaction. SAARC Journal of Tuberculosis, Lung Diseases & HIV/AIDS; 2013; X(2); 48-53 DOI: http://dx.doi.org/10.3126/saarctb.v10i2.9714

Introduction: This study was designed to assess the frequency, types and impact of adverse drug reactions (ADR) to category 1 anti-tubercular therapy using fixed drug combinations (FDC). Patients with tuberculosis started on anti TB treatment from 01st of July 2011 to 30th of June 2012 were recruitedMethodology: Patients were followed up for development of ADR. Frequency of ADR, number of patients who required prolongation of therapy, who had alternate regimes, and there treatment outcome were recorded.Results: Out of 280 patients with tuberculosis 67 (24%), 37 (55.2%) males, 30 (44.8%) females ADR. Thirty three out of 74 (44%) of total population above the age of 60 had ADR, while only 34 out of 206 (16.5%) of patients below the age of 60 had ADR (Chi= 23, p <0.0001). Incidence of ADR were - Dyspeptic symptoms 31(11.1%), itching 20 (7.1%), hepatitis 9 (3.2%), arthralgia 1 (0.4%), vertigo 1 (0.4%), peripheral neuropathy 1 (0.4%), visual impairment 1 (0.4%), rash 1 (0.4%). Out of 27 patients who had prolongation of therapy 22 (81.4%) were due to ADR (Chi = 54, p <0.0001). Nine (3.2%) were given alternate regimes (Fishers exact p = 0.000017) [6 hepatitis, 1 rash, 1 vertigo, 1 visual impairment]. None of the patients with ADR had relapses or treatment failures.Conclusion: Adverse reactions were commoner among the elderly, and were associated with prolongation and modification of anti tuberculosis therapy but over all treatment outcomes were not adversely affected.SAARC J TUBER LUNG DIS HIV/AIDS, 2015 XII (2),Page: 8-12