Implantable biomedical microdevices enable the restoration of body function and improvement of health condition. As the interface between artificial machines and natural tissue, various kinds of microelectrodes with high density and tiny size were developed to undertake precise and complex medical tasks through electrical stimulation and electrophysiological recording. However, if only the electrical interaction existed between electrodes and muscle or nerve tissue without nutrition factor delivery, it would eventually lead to a significant symptom of denervation-induced skeletal muscle atrophy. In this paper, we developed a novel flexible tubular microelectrode integrated with fluidic drug delivery channel for dynamic tissue implant. First, the whole microelectrode was made of biocompatible polymers, which could avoid the drawbacks of the stiff microelectrodes that are easy to be broken and damage tissue. Moreover, the microelectrode sites were circumferentially distributed on the surface of polymer microtube in three dimensions, which would be beneficial to the spatial selectivity. Finally, the in vivo results confirmed that our implantable tubular microelectrodes were suitable for dynamic electrophysiological recording and simultaneous fluidic drug delivery, and the electrode performance was further enhanced by the conducting polymer modification.

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Nowadays, more and more large aperture aspherical mirrors are wildly used in the optical system, many of them with fast ratio and large asphericity. When manufacturing these aspherical mirrors, we can only choose the null testing method, so the null compensators for these surfaces are required. For reduce the residual error and easy to process, the compensator used in the null testing usually accompany by the existence of the ghost image, customarily the ghost image is considered to be useless. In this research we analyze the relationship between the ghost image and the optical axis of the system by study the optical properties of the null testing, find out that adjusting the misalignment of the optical axis not only should eliminate the coma term, but also should rectify the field, the center field also the correct optical axis means that the ghost image should be at the center of the interference image. Then we discuss the auxiliary role of the ghost image in the measurement and adjustment, and apply that to the experiment: null testing a 1.6 meter aspherical mirror by the compensator, which has obvious ghost image in the interferogram, by combined adjusting the compensator and the interferometer during the operation we finally get the optimized method. The result shows that according to the state of the ghost image and with the help of the scientific adjusting method, we can quickly and accurately realize the correction of the optical axis when null testing the aspherical surface by the null compensator, that has important scientific guiding significance for modern manufacturing and testing of the large aperture aspherical mirrors.