Objectives: To document the treatment of refractory chyle leaks using thoracoscopic thoracic duct ligation and provide systematic guidelines to manage chyle leaks. Methods: The medical records of 2 patients with chyle leaks are reviewed, followed by a review of the literature on chyle leaks and their thoracoscopic management. Conclusions: Initial treatment of chyle fistula is aimed at conservative medical management. Persistent high-output fistulas (>500 cm³) should be considered for neck reexploration as conservative management is likely to fail. Thoracoscopic thoracic duct ligation provides a safe and efficient means of treating chyle leaks refractory to repeated surgical and medical intervention. It should also be considered as a primary surgical intervention for patients with: (1) chyle output exceeding 500 cm³/day where prior intraoperative attempts at ligation have failed, (2) severe metabolic and nutritional complications, (3) coexisting chylothorax with respiratory compromise, and (4) low-output fistulas (<500 cm³/day) of long duration (>14 days).

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Background5-hydroxytryptamine 3 (5-HT3) receptors have been known to be associated with the modulation of nociceptive transmission. However, it is uncertain whether 5-HT3 plays a role in the antinociceptive or pronociceptive pathway for incisional pain. In this study, we evaluated the effects of palonosetron, a 5-HT3 receptor antagonist, on incisional pain in rats when administered intrathecally or intraplantarly.MethodsAn intrathecal catheter was implanted through the cisterna magna and placed in the intrathecal space of rats. An incision in the plantaris muscle of the right hind paw was done under anesthesia with sevoflurane. Withdrawal thresholds were evaluated with the von Frey filament after 2 hours. Palonosetron (0.5 and 0.1 µg intrathecally; 0.5 µg intraplantarly) was administered and the thresholds were observed for 4 hours.ResultsMechanical hypersensitivity developed after the incision. Intrathecal palonosetron (0.5 µg and 0.1 µg) did not alter the paw withdrawal threshold. Intraplantar palonosetron (0.5 µg) also did not change the paw withdrawal threshold.ConclusionsIntrathecal and intraplantar palonosetron (0.5 µg) had no effect on modulating the mechanical hypersensitivity in the incisional pain model of rats.

Purpose We modified the hamstring tendon graft into the hamstring-bone composite graft in double-bundle anterior cruciate ligament reconstruction for anterior cruciate ligament (ACL) injuries. Here, we evaluated the technique's effectiveness by investigating the clinical results in restoring the stability and function of the knee joint. Methods We reviewed 42 patients who underwent anterior cruciate ligament reconstruction (ACLR) with the hamstring-bone graft for ACL injuries from January 2013 to April 2015, with an average follow-up of 66.6 months. The objective evaluations (KT-1000, Lachman test and pivot-shift test) and the subjective evaluations (International Knee Documentation Committee (IKDC) scores, Lysholm scores, and Tegner scores) were performed preoperatively and postoperatively. Results Forty-one of 42 patients were negative in the Lachman test and forty of 42 patients were negative in the pivot-shift test after the operation at the final follow-up time. The IKDC, Lysholm, and Tegner scores improved significantly from 56.24±9.28 to 85.33±3.37, from 62.00±11.09 to 90.43±3.71，and from 2.3±0.87 to 6.5±0.67 at the final follow-up. Conclusion Double-bundle anatomic ACLR with a hamstring-bone composite graft can restore the anteroposterior and rotational stability for ACL injuries. The modified technique can provide excellent clinical outcomes with a long-term follow-up.