2021) Circular RNA FAT atypical cadherin 1 (circFAT1)/microRNA-525-5p/spindle and kinetochore-associated complex subunit 1 (SKA1) axis regulates oxaliplatin resistance in breast cancer by activating the notch and

WHAT THIS PAPER ADDS The combination of colour duplex ultrasound (CDU) and contrast enhanced ultrasound (CEUS) was found to be successful in showing the morphological characteristics of isolated mesenteric artery dissection (IMAD), and ultrasound imaging also allowed the detection and assessment of peak systolic velocity at the point of the minimum inner diameter. CDU plus CEUS was as successful as computed tomography angiography alone in the follow up for patients with IMAD, without the need for radiation exposure or iodine containing contrast use. Objectives: The aim was to investigate the effectiveness of colour duplex ultrasound (CDU) plus contrast enhanced ultrasound (CEUS) vs. computed tomography angiography (CTA) for surveillance in patients with isolated mesenteric artery dissection (IMAD). Methods: Patients who underwent CDU, CEUS, and CTA for surveillance of IMAD between January 2012 and May 2019 were included in the study. The accuracy of CDU, CEUS, and CTA for determining the morphological characteristics of IMAD was analysed. Results: A total of 42 patients undergoing 76 total imaging examinations during follow up were included. Both CTA and CDU plus CEUS demonstrated the thrombosed false lumen for 28 (36.8%) examinations and the dissecting aneurysm for 20 (26.3%) examinations (both k ¼ 1.0). The diameter of the dissecting aneurysm was 5.03 AE 1.25 mm using CDU and CEUS vs. 5.27 AE 1.23 mm on CTA (coefficient of consistency, 0.997; p < .001). The entry points were visualised by CDU and CEUS for 20 (26.3%) examinations and by CTA for 14 (18.4%) examinations (k ¼ 0.769); no re-entry points were visualised by CDU and CEUS for any examinations but re-entry points were visualised by CTA for two (2.6%) examinations. The minimum inner diameter was 2.80 AE 1.30 mm on CDU and CEUS vs. 2.52 AE 1.29 mm on CTA (coefficient of consistency, 0.999; p < .001). The peak systolic velocities were 128.2 AE 13.0 cm/s at diagnosis and 98.7 AE 4.9 cm/s after one month (p < .001). Conclusions: The combination of CDU and CEUS can be used in place of CTA for the surveillance of IMAD.

In-stent restenosis (ISR) after stent implantation, especially in tapered vessels, remains an obstacle in the long-term benefits of stenting. In the present study, a finite element method (FEM) was employed to investigate the expansion process of balloon-expandable stents in tapered vessels (the TV model) and their interactions. For comparison, a numerical model of the same stent deployment in a straight vessel was also investigated. Results showed that in the TV model, the peak tissue stresses took place at the distal end of the tapered vessel. The node displacements of the stent's proximal and distal ends remained consistent before the stent contacted the tapered vessel, while the proximal end was larger than the distal end after the stent contacted the tapered vessel. The regions of maximum stresses in the stent after expansion were concentrated in the corners of the diamond cells of the stent's proximal end. The investigation provided some interpretations of the clinical observations in tapered vessels and also provided stent design proposals for tapered vessels. The FEM quantified the mechanical properties of stents in tapered vessels, and can help clinicians select appropriate stents, assist designers in pretests and create new stents made especially for tapered vessels.