Drug-induced liver disease accounts for about 50% of acute or subacute liver failure in the United States. United Network of Organ Sharing (UNOS) data suggest 8%-20% of liver transplantation in this country per year is for fulminant liver failure due to drugs. Even though the most common medication implicated in acute liver injury is acetaminophen (75%), there are numerous other drugs that are responsible for acute and chronic liver injury. A variety of antifungal medications are known to cause a wide range of liver injury from a mild hepatocellular-cholestatic injury pattern to acute/subacute liver failure. Terbinafine is one of the antifungals that have been associated with such liver injuries. We report a case of terbinafine-induced severe liver failure requiring liver transplantation. Liver Transpl 13: 162-164, 2007.
In May 2012, a group of chemical and mechanical engineering students from the newly established [University Name] Appropriate Technology and Sustainability [Identifying Acronym] undergraduate research group embarked on a 10 day visit to Bangang Village, Cameroon in West Africa to implement a multidisciplinary engineering service-based project to develop appropriate, sustainable biodiesel and biochar technology for use by local villagers. The participating students had worked on this design project both as part of their capstone design course in both Chemical and Mechanical Engineering and as part of a special elective that included an embedded study abroad component. Poverty and rapid population growth have led to the accelerated destruction of natural resources throughout the developing world, particularly West Africa. The purpose of this project was not only to introduce students to the concepts of sustainability, service based learning and appropriate technology, but to get them beyond the textbooks and laboratories and solve real problems that impact real people around the world.
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