The health risks of 1,4-butanediol are similar to those of its counterparts, gamma-hydroxybutyrate and gamma-butyrolactone. These include acute toxic effects, which may be fatal, and addiction and withdrawal.

Approximately 70% of male rats receiving severe T8 spinal contusions develop allodynia in T5-7 dermatomes (at-level) beginning two weeks post-injury. In contrast, rats having either complete transections or dorsal hemisections do not develop allodynia at-level following chronic spinal cord injury (SCI). In the present study, incomplete laceration and contusion injuries were made to test for neuroanatomical correlates between areas of white matter damage/sparing at the lesion epicenter and the presence/absence of allodynia. Following incomplete laceration lesions and six weeks of behavioral testing, histological reconstruction and analysis of the lesion epicenters revealed a significant difference (p<.001) in the amount of ventrolateral funiculus (VLF) asymmetry between rats showing pain-like responses evoked by touch (74.5% ± 8.4% side-to-side difference in VLF damage) versus those not responding to touch (11.3% ± 4.4% side-to-side difference in VLF damage). A five week mean allodynia score for each rat that incorporates a full range of forces that are all innocuous in intact controls revealed that the degree of hypersensitivity at level is related to the extent of VLF asymmetry post-SCI. No other damaged spinal white matter or gray matter area was correlated with sensitivity to touch. Similar findings were obtained for rats receiving T8 contusions, a more clinically relevant injury. These data suggest that different extents of damage/sparing between the two sides of VLF are likely a requisite for the development of allodynia after SCI.

\s=b\A one-stage surgical procedure describing the removal of the necessary nasal bones for complete eradication of nasal dermoids, with subsequent replacement of the intact bones, is discussed herein. This technique has proved to be invaluable in two patients who underwent this procedure. Extensive meticulous dissection often is necessary to extirpate this cystic lesion and to prevent its recurrence. Extensive surgery, however, need not result in a notable cosmetic deformity that requires secondary restorative measures. Using this technique, replaced nasal bone segments effect immediate reconstruction. A 20-year review of the cases of nasal dermoids from the Children's

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