A single topical application of mitomycin significantly reduces the severity of LTS in dogs. Reapplication after 2 days does not improve results. Prospective clinical studies are warranted to assess the efficacy in humans.
Laryngotracheal stenosis (LTS) is a serious challenge for the otolaryngologist. Although progress has been made in preventing and treating LTS, more research is required. Existing canine models for LTS incur high mortality and morbidity, require relatively complicated procedures or costly equipment, entail lengthy waiting periods, or have unpredictable results. A simple, reliable, and inexpensive procedure, requiring no tracheotomy, is described for creating a canine model for LTS research. The new improved model is compared with previous models described in the literature. It will be especially useful for short-term studies of subglottic or tracheal stenosis.
\s=b\A one-stage surgical procedure describing the removal of the necessary nasal bones for complete eradication of nasal dermoids, with subsequent replacement of the intact bones, is discussed herein. This technique has proved to be invaluable in two patients who underwent this procedure. Extensive meticulous dissection often is necessary to extirpate this cystic lesion and to prevent its recurrence. Extensive surgery, however, need not result in a notable cosmetic deformity that requires secondary restorative measures. Using this technique, replaced nasal bone segments effect immediate reconstruction. A 20-year review of the cases of nasal dermoids from the Children's
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.