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RESULTS Apoplexy SUBJECTS AND METHODSWe report a retrospective study from 2000 to 2014 of 23 cases with pitu itary apoplexy. Th eir mean age was 3 8.7 +/-10 years, with a male to female ratio of 2:1 . DISCUSSIONIn our stud y apoplexy reveals generally unkn own adenomas . Male sex and functio ning tumours , were major risk factors . The majority of o ur patients had frontal and retro -orbital headaches associated to visual impairement as symptoms . MRI p ituitary imaging was the best diagno sis to ol . It detects hemorraghe in the majority of th e cases . All our patients with PA had a pituitary macroadenoma with important suprasellar extension , so large tu mour size can be associated with a significantly increased risk of PA . Diabetes, Bromocriptine , anti -thrombotic medication and pregnancy can be associated with risk of PA . An event o f PA lead to p ituitary in sufficiency at least in one hormone in the majority of our patients requiring substitution . Our results confirm the findings of so me previous studies in th e literature .