Cutis verticis gyrata and acromegaly

Is IGF‐1 a key player in the pathogenesis of acromegaly‐associated cutis verticis gyrata?

“…Endocrine actions by these hormones on cutaneous target cells, especially dermal fibroblasts, must have induced the skin changes in our patient. This hypothesis is based on the following: firstly, CVG is observed in 14%–30% of patients with acromegaly . It may stabilize or regress upon control of GH secretion after surgical intervention or medication .…”

“…This hypothesis is based on the following: firstly, CVG is observed in 14%–30% of patients with acromegaly . It may stabilize or regress upon control of GH secretion after surgical intervention or medication . A dose dependency between the intensity of CVG and GH/IGF‐1 levels is conceivable but has not been addressed in a study so far.…”

Delayed Diagnosis of Acromegaly in an Elderly Adult that Initially Presented as Cutis Verticis Gyrata

“…Surgical adenomectomy, medical therapy, and radiotherapy are the management options for acromegaly . This woman refused to undergo any surgical procedure, and medical treatment failed to control the hormone levels, as in previous reports . Psychosocial impairment—associated with diagnostic delay in individuals with acromegaly—can partially explain the lack of motivation to agree to therapeutic recommendations and nonadherence to medical therapy, which led to failure in achieving disease control .…”

“…Acromegaly is a rare, slowly progressing metabolic condition caused by a chronic excess of growth hormone, primarily because of the presence of pituitary adenomas . It is characterized by an acquired progressive disfigurement, usually affecting the face, hands, and feet; in rare cases, individuals with these acromegalic features also present with CVG—a very rare cutaneous morphological condition with a pattern resembling the brain surface that commonly affects the scalp and forehead and infrequently affects the glabella and the nasal bridge . Although acromegaly has been described in elderly adults, it is typically diagnosed in the fourth to fifth decade of life .…”

Idiopathic Cutis Verticis Gyrata in a Female

“…First described by Alibert in 1837 [ 1 ], cutis verticis gyrata (CVG), also called "bulldog scalp or corrugated scalp'' [ 2 , 3 ], is a rare, benign and progressively evolving scalp deformity characterized by an excessive proliferation and hypertrophy of the skin and the subcutaneous tissue. The affected area exhibits folds and furrows resembling the convolutions of the cerebral cortex.…”