Introduction. This article investigated the role of oxidative stress in the etiology of pregnancy induced hypertension. The aim of this study was to determine the degree of oxidative stress, and the level of thiobarbituric acid reactive substance in the blood of pregnant women with and without pregnancy induced hypertension and to correlate these parameters with clinical parameters during pregnancy and delivery. Material and Methods. This prospective study was performed at the University Clinical Centre of the Republic of Srpska. It included 200 pregnant women-100 with pregnancy induced hypertension, and 100 healthy normotensive pregnant women between 28 to 40 weeks of gestation. Results. Pregnant women with pregnancy induced hypertension had significantly higher median levels of oxidative stress marker: thiobarbituric acid reactive substance of 36.7 µmol compared to the control group of 13.2 µmol. Pregnant women with pregnancy induced hypertension presenting with complications had significantly higher thiobarbituric acid reactive substance mean levels of 41.6 µmol compared with pregnant women without complications. The highest thiobarbituric acid reactive substance level of 43.9 µmol was found in pregnant women with Hemolysis, Elevated, Liver Ensimes, Low Plateles syndrome. Conclusion. The study showed that thiobarbituric acid reactive substance, as an oxidative stress marker, may be used in clinical practice in the assessment of the severity of complications and as an indicator for timely delivery in women with pregnancy induced hypertension. Further studies and a larger study sample of pregnant women with severe hypertension are necessary to confirm this conclusion.

Introduction: In pregnancy-induced hypertension (PIH) there is a disorder in placental blood flow which causes intrauterine fetal hypoxia, and oxidative stress has a significant role in this condition. The aims of this research were to analyze the relation of thiobarbituric acid reactive substance (TBARS), as a marker of oxidative stress and absent end-diastolic flow (AEDF), as well as the relation of TBARS and cerebroplacental ratio (CPR). Methods: The research included 200 pregnant women in the gestation period from 28th to 40th, 100 were in a control group and 100 were with PIH. The CPR and TBARS were analyzed in all examined pregnant women. The CPR was calculated by dividing the Doppler indices of the middle cerebral artery by the umbilical artery. Results: Mean value of TBARS in the group with the PIH who had AEDF was in the interval of high values - 43.22 μmol/l. The result shows that through the application of Spearman’s coefficient, the correlation results in a statistically significant correlation between CPR and TBARS values: ρ = - 0.249, p = 0.0001. Conclusion: PIH has a very high level of oxidative stress, especially in pregnant women with absent end-diastolic flow in the umbilical artery and pathologic CPR. The Spearman’s test results in statistical significance and negative correlation, which means that in higher TBARS values, values of CPR are lower and vice versa, which indicates a possibility of clinical application of TBARS.

The authors in their paper show the case with the female patient D.S. 51 years old, which was surgically treated for genital condyloma in 1981, 1986, 1999, 2006 and 2008. Under registration number 3119/2006 was received at Gynecology and Obstetrics Clinic in Banja Luka with the diagnosis of condyloma acuminatum permagnum. Patient suffered from a huge tumorous, cauliflower formation, which was located on the mons pubis, and down to the anus, laterally to the right of the gluteal region to the left thigh. Patient was operated–Vulvectomia simplex cum extirpatio tumoris reg glutealis l dex. We obtained pathohistological findings (no. 4876 / 06) which read: condyloma acuminatum permagnum. After two years patient was rehospitalized at Gynecology and Obstetrics Clinic in Banja Luka, (registration number 1311/08) with almost identical findings in the same region under the diagnosis of condyloma acuminatum permagnum recidivans, St. post. vulvectomiam simplex et extitpationem tumoris glutealis reg l dex. All preoperative findings – laboratory analysis, X-ray of the lung and heart and ultrasound of the small pelvis were within the reference values. In this paper we describe the location of the tumor and how it is resolved – Extirpatio tumoris reg glutealis l. dex. et perianalis.Pathohistological findings confirmed previous diagnosis. In this paper we highlight our experiences regarding the operations of an unusually large tumors of genital condyloma and recurrent genital condyloma that were almost of the same size. Our experience could be useful to work on the education about sexually transmitted diseases, in order to improve the prevention of the viral diseases (vaccination), the treatment of these illnesses and to disseminate the warning that the regular check-ups with gynecologist are necessary.