The quality of existing evidence on the impact of shift duration on fatigue and fatigue-related risks is low or very low. Despite these limitations, this systematic review suggests that for outcomes considered critical or important to EMS personnel, shifts <24 hours in duration are more favorable than shifts ≥24 hours.

In this systematic review, limited evidence of the reliability and validity of 14 different survey instruments to assess the fatigue and/or sleepiness status of EMS personnel and related shift worker groups was identified.

Conformational Changes in the Cytoplasmic Region of KIR3DL1 upon Interaction with SHP-2 Highlights d KIR3DL1 cytoplasmic domain is intrinsically disordered with three distinct segments d TFE and SDS enhanced a-helical conformation around the two tyrosines (ITIMs) d SHP-2 SH2 domains decrease NMR peaks around the unphosphorylated N-terminal ITIM d Bis-phosphorylated ITIMs are more broadly impacted by the tandem SHP-2 SH2 domains

The effect of task load interventions on fatigue, fatigue-related risks, and/or sleep quality was not estimable and the overall quality of evidence was judged low or very low. There was considerable heterogeneity in how task load was defined and measured.

No abstract