In this study, an E-Nose system was realized for the anesthetic dose level prediction. For this purpose, sevoflurane anesthetic agent was measured using the E-Nose system implemented with sensor array of quartz crystal microbalances (QCM). In surgeries, anesthetic agents are given to the patients with carrier gases of oxygen (02) and nitrous oxide (N20). Frequency changes on QCM sensors to the eight sevoflurane anesthetic dose levels were recorded via RS-232 serial port. A multilayer feed forward artificial neural network (MLNN) structure was used to provide the relationship between the frequency change and the anesthetic dose level. The MLNNs were trained with the measured data using Levenberg-Marquardt algorithm. Then, the trained MLNNs were tested with random data. The results have showed that, acceptable anesthetic dose level predictions have been obtained successfully.