The article examines modern approaches to the problem of psychoemotional disorders and, in particular, anxiety syndrome in psychosomatic pathology. Special attention is paid to the somatic «masks» of the anxiety syndrome in the most common clinical forms of psychosomatics, as well as the role of chronic stress in the pathogenesis of the specified syndrome and in the occurrence of neurotransmitter imbalance, which is the basis of the development of anxiety disorders. The advantages and disadvantages of the main groups of drugs used to treat anxiety in patients with various nosological forms of psychosomatic pathology are analyzed. In this regard, special attention is paid to the possibilities of combined phytotherapeutic agents. The advantages of the combination within one dosage form of plant components with proven synergistic anxiolytic action are emphasized. This combination is the original domestic phytotherapeutic agent, which for the first time contains a combination of Vitania extract, L-theanine and Passiflora extract. The peculiarities of the mechanisms of action of each of the components of the specified combination and the justification of the expediency of their combination from the point of view of the impact on the main pathogenetic mechanisms of the development of the anxiety syndrome are considered. Special attention is paid to the issue of safety during therapy with the specified agent as one of the leading criteria for choosing a tool for the treatment of psycho-emotional disorders in psychosomatic pathology. Reasoned expediency of using the considered phytotherapeutic combination in the treatment of various clinical forms of anxiety disorders in general medical practice.