Purpose: Here, we evaluated the safety and effectiveness of Jeonnam's unique resources, such as Dendropanax, sea salt, spinach, and kelp, to develop functional cosmetics that may alleviate hair loss. Methods: We performed safety tests with these resources, testing for heavy metals and cytotoxicity, and we evaluated their effectiveness as anti-microbial, cell proliferation, and anti-inflammation products. Results: The heavy metals concentration was lower than or in trace levels, as recommended by the Ministry of Food and Drug Safety's standard of extracts such as Dendropanax, sea salt, etc. We confirmed cytotoxicity to be safe. In each extract, the concentrations of Dendropanax, sea salt, spinach, and kelp were 0.01 mg/mL, 5 mg/mL, 0.5 mg/mL, 0.5 mg/mL, respectively. Only the Dendropanax extract had microbial effect, with the distilled water extract reaching the highest effect. The cell proliferation increased to 0.5 mg/mL, 5 mg/mL, and 2 mg/mL for Dendropanax, spinach, and kelp with distilled water extract, the anti-inflammation effect increased. Conclusion: We found that Dendropanax, sea salt, spinach, and kelp were safe and effective as functional cosmetic materials to alleviate hair loss symptoms through optimal standardization. We suggest further research to evaluate these cosmetics' functional effects.

Purpose: In this study, we tried to develop differentiated natural cosmetic materials through the standardization of optimal raw materials, and demonstrate complex functionality with anti-oxidative and whitening effects of natural extracts of sprout Panax ginseng C.A. Meyer and Cassia nomame (Sieb.) Honda. Methods: In this experiment, the research materials, sprout Panax ginseng C.A. Meyer and Cassia nomame (Sieb.) Honda, were prepared by identification of genetic analysis, complex extracts of sprout Panax ginseng C.A. Meyer and Cassia nomame (Sieb.) Honda were determined to have optimum anti-oxidative and whitening effects by studying the mixture ratio, solvent ratio, extraction temperature, and extraction time. The standard compound was prepared from the final complex extract. Results: The mixture ratio of sprout Panax ginseng C.A. Meyer and Cassia nomame (Sieb.) Honda with optimum anti-oxidative and whitening effects was 1:9, extraction solvent was 30% ethanol, extraction temperature was 80℃ and extraction time was 8 h. The antioxidative activity of the complex extract showed 49.6% 1.1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity at 500 μg/mL. In a tyrosinase inhibitory activity assessment, the complex extract showed 109% tyrosinase inhibitory activity at 2,000 μg/mL. The standard compound was confirmed to be Schaftoside. Conclusion: This study reveals key conditions for the standardization of manufacturing process to obtain optimal anti-oxidative and whitening effects from complex extracts of sprout Panax ginseng C.A. Meyer and Cassia nomame (Sieb.) Honda. We expect that the use of industrial cosmetics as raw materials for cosmetics, including Shaftoside, will not be hampered by limitations in industrial use due to international patent disputes and high costs.

Purpose: This study was conducted to select the optimal mixing ratio (OMR) of extracts including Dendropanax, sea salt, and others from Jeollanam-do and to develop functional cosmetics that can help alleviate hair loss symptoms.Methods: Our research team determined the OMR through cytotoxicity and cell proliferation tests, and confirmed the anti-inflammatory and anti-microbial effects of the final selected OMR.Results: The cytotoxicity was low when the OMR was 0.1:1:5:1, but cell proliferation was high, and anti-inflammatory activity effectively inhibited the expression of IL–6 and iNOS. The anti-microbial activity also had an effect on Pseudomonas aeruginosa and Staphylococcus aureus.Conclusion: This study selected OMR (1:0.1:5:1) to develop functional cosmetics that can help alleviate hair loss symptoms. The final selection of OMR confirmed low cytotoxicity, high cell proliferation, inhibition of expression of IL–6 and iNOS, and anti-microbial activity. Therefore, it is expected to serve as a functional cosmetic that can help alleviate hair loss symptoms in the future.

Purpose: Because of their unique biological and technological properties, the potential of marine resources in cosmetic applications is well recognized. In this study, we performed a comparative analysis to investigate the safety and quality of various potential marine resources for healing and clinical applications were collected from four regions in South Korea: Uljin, Goseong, Wando, and Taean. Methods: A total of seven types of potential marine resources for healing (peat, mud, sea sand, seaweed, black pine, saline ground water, and sea water) and nine types of marine resources for clinical applications (namely, peat, mud, sea mustard, laver, black pine, sea salt, oyster, oyster boiled water, and saline ground water). Following pre-treatment of samples, we used inductively coupled plasma optical emission spectrometry (ICP-OES) to detect, chemically analyze, and quantify the concentrations of seven heavy metals and useful components (lead, arsenic, cadmium, potassium, sodium, calcium, and magnesium) in the marine samples.. Furthermore, a mercury analyzer was employed to detect and evaluate the concentration of mercury, a common ingredient used in skin lightening soaps and creams. Results: Results of the heavy metal analysis confirmed that marine resources for healing and for clinical applications conform to all safety standards of cosmetics at the Ministry of Food and Drug Safety. Hence, they are suitable for cosmetic applications. However, the lead content of arsenic and peat resources in seaweed was found to be high. In addition, the results of this quality comparison analysis were found to be similar to the control experiments, despite the fact that minor differences were identified between each resource. More specifically, the lead content in peat was increased, whereas the potassium content was decreased. Conclusion: In this study, the comparative analysis of heavy metals and other useful components from four local marine healing resources demonstrated that these resources are both safe and suitable for healing applications. In the future, it is expected that marine resources for healing will be utilized throughout the marine industry through more continuous and systematic research, management and supervision of industries, universities, research institutes, and government policies.