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Catalytic asymmetric reduction of prochiral ketones with hydrides such as boranes and borohydrides is one of the simplest and the most convenient methods for obtaining chiral alcohols. This tutorial review describes the most significant advances recently achieved for enhancing the enantioselectivity and practicability of the reduction using this methodology. The review covers the development of new homogeneous and/or immobilized catalysts for asymmetric reduction using borane or borohydride reagents and practical improvement of the well-known oxazaborolidine (OAB)-catalysed reduction through developing more stable, cost effective and recoverable OABs, scalable and environmental friendly borane sources, and one-pot procedures for the reduction.

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Amines Q 0120 Direct and Indirect Reductive Amination of Aldehydes and Ketones with Solid Acid Activated Sodium Borohydride under Solvent-Free Conditions. -The process provides a simple, convenient, widely applicable, and environmentally friendly method to prepare diverse amines. -(CHO*, B. T.; KANG, S. K.; Tetrahedron 61 (2005) 24, 5725-5734; Dep. Chem., Hallym Univ., Chunchon 200-702, S. Korea; Eng.) -Jannicke 42-083