, and NS3 were recognized HCV-specific CD8/ cytotoxic T lymphocytes (CTL) able less frequently. This recognition pattern was not related to recognize and kill target cells expressing core, E1, to the therapy with IFN-a nor to the clinical response E2, and NS2 proteins in an HLA class I restricted manof the patient toward this therapy. The response to the ner, could be isolated from liver tissue of chronic hepaCore protein could be fine-mapped to the COOH-termi-titis C patients. [5][6][7] In addition, peripheral blood mononuclear cells (PBMC) from such patients also displayed CTL responses to core, NS3, NS4, and NS5 epitopes

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