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No abstract

HLA. antigen frequencies were determined in patients who had suffered adverse reactions to the ^-adrenergic biocking agent, practolol. No statistically significant differences were observed between these patients and control groups. The latter were selected to include rwo separate groups, normal random healthy population controls, and controls who had taken practolol with no apparent adverse effects. Patients suffering from the very severe torm of reaction, sclerosing peritonitis, were analvsed separately from those with other lesions e.g. tx:uiar symptoms, but did not show any signifiant differences. Altered HLA antigen frequencies were observed for those control patients whose primary diagnosis was hypertension but this was considered to be due to seleaion bias.