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Abstract:The past decade has seen growing interest in the investigation of peptides with antimicrobial activity (AMPs). One approach utilized in infection control is incorporation of antimicrobial agents conjugated with the polymers. This review presents the recent developments on polymeric AMP carriers and their potential applications in the biomedical and pharmaceutical fields.

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A series of biomedical polyurethane elastomers (PURs) based on poly(ester‐carbonate)s (PECs) and polycarbonates (PCs) were synthesized and spectrally characterized fully. PEC or PC diols were synthesized by the ring‐opening polymerization of ε‐caprolactone, trimethylene carbonate, and neopentyl carbonate catalyzed by lipase from Candida antarctica. PURs were prepared by free‐metal method from PEC or PC diols and 4,4′‐methylenebis(phenyl isocyanate), with 1,4‐butanediol as a chain extender. The physical and mechanical properties as well as hydrolytic stability of the obtained PURs were determined. The toxicity of the received polymers was evaluated using bacterial luminescence test and two protozoans assays. The presented preliminary studies suggest that PEC or PC diols prepared in this way might be applied for the synthesis of biomedical PURs with improved hydrolytic stability. © 2012 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem, 2012

ABSTRACT:Rubber elements, which usually form a major part of different isolators of vibrations, are generally easily swelled by oils, greases, or fuels. This leads to meaningful changes of their mechanical characteristics and shortening of durability of rubber components in service. The influence of the semisynthetic motor oil on mechanical and, particularly, dynamic properties of swelled vulcanizates of the polar diene rubber, chloroprene (CR) and acrylonitrilebutadiene (NBR), is estimated in this article. These elastomers, as is widely known, are resistant to the mineral oils absorption. However, our investigations showed that even a small degree of swelling of the vulcanizates causes decrease of their mechanical properties and considerable changes of the dynamic characteristics of the samples. The obtained results have shown the need to take into account the environment in which isolators of vibrations and dampers have worked, while designing the suitable composition of rubber compounds.