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Teicoplanin in a 400 mg intravenous loading dose followed by 200 mg/day intravenously or intramuscularly was given to 19 patients with deep-seated staphylococcal infections. Only eight patients (44.4%) were considered cured, failure mostly being observed in patients with osteomyelitis, endocarditis and bacteremia. Poor tissue kinetics of teicoplanin and the presence of foreign bodies are probable explanations for the reported failures. Future trials using a higher dose of teicoplanin with or without the addition of rifampicin or gentamicin seem to be justified.

Objective: Current cardiovascular risk assessment in primary prevention results in over and under treatment of individual patients although on an epidemiological level benefit has been shown. A trend towards personalized medicine is emerging assuming considerable inter-individual atherosclerotic variation. After risk categorization, further individualized diagnostic workup may be feasible. We hypothesized that carotid artery vessel wall (CAVW) assessment using 3 Tesla MRI could show atherosclerotic variation in a homogeneous group stratified for cardiovascular risk.Design and Method: One hundred and sixteen men (age 59.0 AE 5.18years) with visceral obesity and CRP ¼>1.8 mg/L were included. Patients were selected for not having suffered from a cardiovascular event. In all individuals the predicted 10-year risk of mortality due to CVD was assessed using Framingham scores. Patients were stratified according to their risk score as follows: 5-9%, 10-14%, 15-19% and ¼>20%/10 years risk .CAVW characteristics were assessed using black blood 3T MR vessel wall imaging, a precise and reproducible technique (JMRI 2007; 25:1035-43).

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