During the Project "Mars-500" in months-long examination, 17 residents of Syktyvkar and 18 residents of Magadan were examined. A number of common morphological and physiological methods of study and the hardware and software complex "Ecosan-2007" were used. It has been established that the highest tension in hemodynamics reaction was characteristic of the residents of Magadan living in more extreme climatic conditions and, to a greater degree, it was more pronounced in winter (increased systolic BP and total peripheric vascular resistance) along with formation of a correlated structure of these indices. The peak tension of functional state in the residents of Syktyvkar was observed in summer and was characterized by the increased heartbeat, diastolic BP, the decreased heart rate, display of dysadaptation, increasing centralization between parameters of hemodynamics and the heart rate. Seasonal dynamics of morphofunctional indices was more pronounced in the residents of Syktyvkar.