Poster abstracts decided to follow up the pregnancy during two weeks and perform the cordocentesis in this time, karyotópe was normal. At 26 weeks we found progressive changes in fetal anatomy: heart herniation became larger, left lobe of liver began to protruse, the absence of the sternum and cartilaginous parts of the ribs was confirmed. Patient was offered pregnancy termination because of the impossibility of surgical correction. Radiography, CT and morphology of abortus confirmed ultrasound diagnosis of isolated absence of the sternum and cartilaginous parts of the ribs.
P02.39Nuchal translucency in screening for congenital heart defects in chromosomally normal fetuses Objective: Assess the accuracy of the nuchal translucency (NT) measurement between 11 weeks and 13 weeks and 6 days of gestation as a sonographic marker to screen for congenital heart defects (CHD). Methods: Multicentric retrospective study, analyzing single pregnancies from euploid fetuses. NT measurement was performed in the first trimester, when fetuses had from 45 to 84 mm of crownrump length (CRL), according to the criteria established by the Fetal Medicine Foundation. Different cut-off point were used to define enlarged NT (95th and 99th centiles, 2.5, 3.0 and 3.5 mm). Cardiac anomalies were evaluated either by echocardiography or by clinical examination during the first month of life. Results: 3,664 pregnancies were analyzed and 20 newborns had CHD diagnosed until the first month of life (prevalence of 0.55%). The median NT of the fetuses with CHD was 1.70 mm and 1.60 mm for fetuses without CHD. No significant difference was found (Mann-Whitney test, p > 0.05). The sensitivity of NT in detection of CHD varied from 15 to 20%, with a range of false positive probability from 86.4 to 97.9%, depending on the cut-off point used. However, the odds ratio was high, when compared to the classic indications of echocardiography, ranging from 4.7 to 33.7 according to the cut-off point. Conclusion: In spite of the low sensitivity of the test, enlarged NT is an important risk factor for CHD and should be used in prenatal screening for CHD.
P02.40The influence of maternal age on the association of an isolated fetal intracardiac echogenic focus and fetal aneuploidy C. E. Interthal, A. G. Puhl, C. Lindner, V. Passuello, D. Macchiella, E. Steiner, H. Koelbl
Department of Obstetrics and Gynecology, University of Mainz, GermanyBackground: Fetal intracardiac echogenic foci (IEF) have frequently been reported to be associated with fetal aneuploidy. The overall incidence of IEF ranges from 0.17% to 20 varying with background risk. Data on this association remains inconclusive, while an association was shown in initial studies, recent studies differentiating between different risk groups could not reproduce those findings in low risk populations. Objective: To evaluate the incidence of IEF and its association with fetal aneuploidy in patients referred to our prenatal department for 2nd-trimester genetic sonogram. Method: We performed a retrospective chart analy...
