The psychosomatic aspects of skin disease were studied both clinically and experimentally, from the standpoint of immunology. We found that emotional stress has a great influence on the immune system, as was manifested in skin disease. Skin test in allergic patients significantly improved with autogenic training and relaxation. For clarification of the effects of autogenic training and relaxation, various parameters were simultaneously assessed during the treatment. The serum levels of histamine and dopamine-Β-hydroxylase fluctuated, as determined by the microvibration test. The levels of IgE and findings on the PK test varied only slightly. Before the onset of urticaria, there were changes in the life-style and considerable stress in daily life as well as exposure to an allergen. Using mice subjected to stress, the functions of T cells and macrophages were evaluated. Stress appeared to have a definite influence on the functions of these cells, as related to the important role of the immune system and skin. Thus, the role of stress in clinical disease must always be given consideration.

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The effects of adrenergic agents on bovine ciliary muscle were studied in vitro. Norepinephrine, phenylephrine, or isoproterenol did not affect the muscle tone. High concentrations of guanethidine (10 M) partly inhibited the nerve-mediated contractions of the muscle. The nerve-mediated contractions also were inhibited in the following order : norepinephrine > epinephrine > > isoproterenol. The inhibition was blocked by yohimbine or phentolamine, but not by optimum concentrations of prazosin, moxisylyte, propranolol, and carteolol. Usual concentrations of phosphodiesterase inhibitors markedly inhibited the nerve-mediated and carbachol-induced contractions.These results suggest that an adrenergic »2 receptor located at the nerve terminals inhibits the contraction of cholinergically innervated ciliary muscle. Adrenergic innervation seems to play an inhibitory role in the muscle tissue when the muscle tone is elevated.

To determine the characteristics of astigmatism 1 week postoperatively or whether the final astigmatism is predictable from that present 1 week postoperatively, we analyzed 544 postcataract against-the-rule (AR) cases of astigmatism among 1,649 standard phacoemulsification cataract operations, all utilizing 10–0 Mersilene in double-running fashion. Postoperative AR astigmatism ≤1.0 dpt increased markedly 1 week postoperatively (2.72 ± 0.09 dpt) but decreased 6 months postoperatively. However, in postoperative AR astigmatism > 2.0 dpt, the increase 1 week postoperatively was not as great (2.16 ± 0.13 dpt) but tended to continue to increase even 6 months postoperatively, with a flatter corneal curvature being the responsible factor. Eyes with less astigmatism 1 week postoperatively showed exacerbation of final astigmatism 6 months postoperatively. This course was different from that of small incision cataract surgery.

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