Introduction: Rheumatoid arthritis is a chronic inflammatory polyarthritis of relatively common occurrence affecting about 1-2% of adult population world-wide and 0.75% of Indian adults. The disease occurs at all ages and affects all ethnic groups. For early diagnosis and progression of rheumatoid arthritis might be useful for to better treatment of the patients.  Present study aimed to assessment of adiponectin in newly diagnosed and remission rheumatoid arthritis patients. Materials and Methods: 100 Rheumatoid arthritis patients and 50 healthy volunteers with matching age, gender, and BMI were included in the study. All the subjects' biochemical, disease activity score, RA factor,ESR Rheumatoid Arthritis Patients and serum adiponectin levels were assessed. SPSS and Microsoft Excel Spreadsheets were used to conduct the necessary statistical analysis. Results: The patients with rheumatoid arthritis shown significantly higher levels of fasting blood sugar, postprandial blood sugars ,triglycerides , RA factor, ESR when compared to healthy controls (P=0.001**). Additionally we also discovered to be considerably significantly elevated levels of serum adiponectin (P= 0.001**). Furthermore there was very high significant positive correlation between serum adiponectin and disease activity score, RA factor, ESR.