Co-intake-related interactive-synergistic influence of artemether-lumefantrine, AL and monosodium glutamate, MSG that separately mediated oxidative stress could be significant on the kidney actively involved in xenobiotic detoxification and elimination. Thus, influence of AL on rats’ kidney histomorphology and antioxidant bio-indicators following MSG-challenge was assessed. For 7 days, thirty rats (n = 5) were respectively exposed to vehicle (distilled water), therapeutic AL (TAL), high AL (HAL), MSG, MSG plus TAL or MSG plus HAL. Significant (P<0.05) results comparison showed highest and least (P<0.05) albumin concentration (Mg/dl) in TAL-fed (3.76±0.33) and MSG-fed (1.88±0.70), rats. Total protein concentration (Mg/dl) in MSG-fed (4.04±2.04) and HAL-fed (4.76±1.92), rats lowered markedly. Highest glutathione peroxidase activity (IU/L) in TAL-fed (30.74±12.46) lowered in MSG plus HAL-fed (20.11±6.08) and MSG-fed (20.33±4.85), rats. Catalase activity (IU/L) in control was highest (4.89 ± 0.26) but least (2.58 ± 1.06) in MSG-fed rats. Zinc and Magnesium concentration (Mg/dl) was respectively highest (58.99±5.10) and least (3.48±0.31) in MSG plus HAL-fed but least (18.80±7.77) and highest (4.38±1.67) in MSG-fed, rats. Malondialdehyde concentration (µmol/ml) in MSG plus HAL-fed rats (4.04±0.67) was highest (P<0.05) and least (P<0.05) in HAL-fed rats (1.18±0.11). Differences in superoxide dismutase activity (IU/L) were, however, non-significant (P>0.05).Rats’ kidney photomicrographs (H&E × 400) revealed normal histo-architecture in control but varied degree of fibroplasias (TAL- ,HAL- and MSG plus TAL-fed) and necrosis with infiltrations (MSG plus HAL-and MSG-fed), rats. These demonstrated MSG-related adversity and significant modulation response of TAL, unlike HAL, on the rats’ kidney histology and studied antioxidant response bio-indicators.