The disproportionately high rates of coronavirus disease 2019 (COVID-19) health complications and mortality among older adults prompted supportive public responses, such as special senior early shopping hours and penpal programs. Simultaneously, some older adults faced neglect and blatant displays of ageism (e.g., #BoomerRemover) and were considered the lowest priority to receive health care. This article examines positive and negative responses toward older adults in the United States during the pandemic and the consequences for older adults and society using data from the pandemic in the United States (and informed by data from other countries) as well as past theorizing and empirical research on views and treatment of older adults. Specifically, positive responses can reinforce the value of older adults, improve older adults' mental and physical health, reduce ageism, and improve intergenerational relations, whereas negative responses can have the opposite effects. However, positive responses (social distancing to protect older adults from COVID-19 infection) can inadvertently increase loneliness, depression, health problems, and negative stereotyping of older adults (e.g., helpless, weak). Pressing policy issues evident from the treatment of older adults during the pandemic include health care (triaging, elder abuse), employment (layoffs, retirement), and education about ageism, as well as the intersection of ageism with other forms of prejudice (e.g., racism) that cuts across these policies. Public Significance StatementThis article explores positive and negative responses toward older adults during the COVID-19 pandemic and the expected short-and long-term consequences such as impacting beliefs about and treatment of older adults, intergenerational relations, and individuals' mental and physical health. This article discusses policy changes to health care (triaging, elder abuse), employment (layoffs, retirement), and education about ageism.

Objective. Liver disease is a potential complication from using dietary supplements. This study investigated an outbreak of non-viral liver disease associated with the use of OxyELITE Pro™, a dietary supplement used for weight loss and/or muscle building. Methods. Illness details were ascertained from MedWatch reports submitted to the U.S. Food and Drug Administration (FDA) describing consumers who ingested OxyELITE Pro alone or in combination with other dietary supplements. FDA's Forensic Chemistry Center analyzed samples of OxyELITE Pro. Results. From February 2012 to February 2014, FDA received 114 reports of adverse events of all kinds involving consumers who ingested OxyELITE Pro. The onset of illness for the first report was December 2010 and for the last report was January 2014. Thirty-three states, two foreign nations, and Puerto Rico submitted reports. Fifty-five of the reports (48%) described liver disease in the absence of viral infection, gallbladder disease, autoimmune disease, or other known causes of liver damage. A total of 33 (60%) of these patients were hospitalized, and three underwent liver transplantation. In early 2013, OxyELITE Pro products entered the market with a formulation distinct from products sold previously. The new formulation replaced 1,3-dimethylamylamine with aegeline. However, the manufacturer failed to submit to FDA a required “new dietary ingredient” notice for the use of aegeline in OxyELITE Pro products. Laboratory analysis identified no drugs, poisons, pharmaceuticals, toxic metals, usnic acid, N-Nitroso-fenfluramine, pyrrolizidine alkaloids, aristocholic acid, or phenethylamines in the products. Conclusions. Vigilant surveillance is required for adverse events linked to the use of dietary supplements.

Background and Objectives Benevolent and hostile ageism are subtypes of ageism that characterize older adults as incompetent. With benevolent ageism, older adults are also viewed as warm. The COVID-19 pandemic has strained resources and prompted debates about priority for older adults versus other groups. Research Design and Methods College students completed an online survey of how much priority should be given to older adults in three relevant healthcare-related scenarios and three relevant employment scenarios. Results Benevolent ageism significantly predicted higher priority for older adults to receive healthcare (triage, COVID-19 vaccine, COVID-19 testing) and employment resources (retention of job, working from home) while greater endorsement of hostile ageism significantly predicted lower priority ratings. Discussion and Implications These findings replicate and extend past work. As the COVID-19 pandemic continues to wreak havoc on healthcare and employment resources, this study sheds light on one factor -- benevolent and hostile ageism -- that contributes to a greater understanding of prioritization views toward a vulnerable segment of the population.

Background Rapid spread of SARS-CoV-2 has led to a global pandemic, resulting in the need for rapid assays to allow diagnosis and prevention of transmission. Reverse transcription-polymerase chain reaction (RT-PCR) provides a gold standard assay for SARS-CoV-2 RNA, but instrument costs are high and supply chains are potentially fragile, motivating interest in additional assay methods. Reverse transcription and loop-mediated isothermal amplification (RT-LAMP) provides an alternative that uses orthogonal and often less expensive reagents without the need for thermocyclers. The presence of SARS-CoV-2 RNA is typically detected using dyes to report bulk amplification of DNA; however, a common artifact is nonspecific DNA amplification, which complicates detection. Results Here we describe the design and testing of molecular beacons, which allow sequence-specific detection of SARS-CoV-2 genomes with improved discrimination in simple reaction mixtures. To optimize beacons for RT-LAMP, multiple locked nucleic acid monomers were incorporated to elevate melting temperatures. We also show how beacons with different fluorescent labels can allow convenient multiplex detection of several amplicons in “single pot” reactions, including incorporation of a human RNA LAMP-BEAC assay to confirm sample integrity. Comparison of LAMP-BEAC and RT-qPCR on clinical saliva samples showed good concordance between assays. To facilitate implementation, we developed custom polymerases for LAMP-BEAC and inexpensive purification procedures, which also facilitates increasing sensitivity by increasing reaction volumes. Conclusions LAMP-BEAC thus provides an affordable and simple SARS-CoV-2 RNA assay suitable for population screening; implementation of the assay has allowed robust screening of thousands of saliva samples per week.

The proportion of US food that is imported is increasing; most seafood and half of fruits are imported. We identified a small but increasing number of foodborne disease outbreaks associated with imported foods, most commonly fish and produce. New outbreak investigation tools and federal regulatory authority are key to maintaining food safety.