The objective of this study was to discuss the use of drugs in patients submitted to enteral nutritional therapy. The study had a cross-sectional, observational design of a quantitative nature, in which 30 patients of both sexes, older than 18 years, were admitted to the emergency room of a public hospital in a city in the interior of São Paulo, who were using Nutritional Therapy Enteral, with drugs prescribed by the tube. In the results it was verified that of the total of drugs that were used, 42.85% presented some type of interaction with the nutrients of the diet, being 87.5% of negative interactions; 12.5% of positive interactions and 7.14% did not find any type of interaction. In conclusion, it was observed that there are numerous situations that cancause interactions between the prescribed drugs and the enteral diet, leading to nutritional and drug deficiencies, reducing the effectiveness of both, contributing to depletion of the patient's nutritional state and hindering its recovery.