No abstract

Bacterial nanocellulose (BNC) is a nanofibrillar polymer produced by aerobic bacteria of the genus Gluconacetobacter. The use of BNC as a wound dressing is a novel biotechnology and unique strategy indicated for chronic and acute wound treatment as it has a set of features that will contribute to efficient skin recovery. Studies have reported that BNC can be more effective in healing capacity when compared to other wound dressings providing benefits for the patient and the health system. Our purpose was to summarize such clinical evidences bringing studies that could support the use of BNC as a dressing in many forms and its possibilities for the future. Methods: We conducted a scoping review following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews. Databases were searched for relevant articles without restriction about publication year or period. Inclusion criteria: Articles that report the use of BNC in the healing of acute or chronic wounds through clinical tests were included in the analysis. Articles that have performed preclinical tests (in vivo and in vitro) were excluded from the analysis. Results: We have found sixteen articles using the protocol criteria. The development of the present study made possible to evaluate the extent of clinical use of the BNC dressing, through available evidences on its use for the treatment of chronic and acute wounds. When analyzing the results, it became evident that BNC is a promising biotechnological resource for the effective healing of chronic and acute wounds.

OBJETIVO: Identificar as alterações mais recentes realizadas na superfície da NCB, descrevendo e avaliando o efeito destas modificações no tratamento de feridas MÉTODOS: Foi realizada uma revisão integrativa da literatura entre os meses de dezembro de 2021 e janeiro de 2022 buscando artigos originais encontrados na íntegra em português e inglês publicados nos últimos dez anos nas bases de dados BVS, Cochrane Library, Embase e MEDLINE via Pubmed. RESULTADOS: Foram identificados 646 artigos no total através da busca eletrônica nas bases de dados, entretanto após análise criteriosa foram selecionados 30 estudos que atendiam aos critérios de inclusão. Esses estudos evidenciaram resultados positivos da redução dos níveis de inflamação e do tempo de cicatrização, na melhora da dor, no combate à microrganismos, na redução da área das feridas além de demonstrar aumento na proliferação celular. CONCLUSÃO: Foi possível observar que os pesquisadores estão cada vez mais empenhados em desenvolver compostos inovadores que estimulem o processo cicatricial. No presente estudo foi evidenciado que a Nanocelulose Bacteriana pura é um excelente biomaterial para aplicação em tecidos lesionados, porém, quando esta tem a sua superfície alterada através da incorporação de diferentes ativos, tem-se uma otimização das suas características tornando-a um recurso biotecnológico de alto padrão para a cicatrização de feridas. Sugere-se o investimento em estudos que avaliem outras possibilidades de alterações na superfície da Nanocelulose Bacteriana, visto que esta é uma partícula inovadora de fácil manuseio e de alta eficácia no tratamento de feridas.

Nanocellulose (BNC) is a natural polymer produced by bacteria. Its structure has only glucose monomer, it has various properties such as high water holding capacity, unique nanostructure, high crystallinity and high mechanical strength. Pure BNC or in combination with different components can be used for a wide range of applications. Aloe vera is a medicinal plant with polysaccharides in its composition that has a potential for tissue regeneration and repair. The aim of this study was to evaluate the effect of incorporating Aloe vera (A. vera) into BNC membranes produced with three fractions of A. vera extract (BNC-Aloe) on the behavior of epithelial cells. Human fibroblasts and keratinocytes were shown to have increased metabolic activity and proliferation when cultured on BNC-Aloe membranes compared to control. Quantification of collagen biosynthesis was significantly higher in BNC-Aloe membranes. In conclusion, BNC-Aloe membranes are suggested as a material for the purpose of skin tissue repair.