Resumo: O projeto Integra -Ação Sorriso é desenvolvido por graduandos e mestrandos em Odontologia -UEL/PR com o objetivo de promover atendimento odontológico em crianças e adolescentes em situação de vulnerabilidade social, atendidas pela Instituição Casa Acolhedora Mãe e Senhora de Todos os Povos, Londrina-PR, e instruir quanto à prevenção de doenças e promoção de saúde, principalmente a saúde bucal. Os alunos promoveram ações culturais e educativas com 85 crianças e familiares, incluindo atendimento odontológico, instrução de higiene bucal e fornecimento de material de higiene bucal. Foram oferecidas também orientações por oficinas sobre saúde bucal, instrução quanto à gravidez na adolescência e doenças sexualmente transmissíveis, alimentação saudável, tabagismo e traumatismo dentário. Também foram desenvolvias atividades educativas e culturais, como o Trote Solidário dos calouros do Curso de Odontologia e comemoração de datas festivas, chamando a atenção para a temática de saúde, além de arrecadação de material escolar e brinquedos. A integração de alunos com a comunidade permitiu a formação de profissionais capacitados para atuar em prevenção e conscientes de seu papel na atenção às demandas sociais. Foi possível ainda perceber a necessidade de estender o atendimento odontológico para atendimento aos pais, devido ao progresso dos tratamentos das crianças e adolescentes.Palavras chave: Extensão comunitária; cárie dentária; crianças; prevenção; saúde coletiva. Abstract: The 'Integra' project -Smile Action is developed by undergraduate and Master's degree students in Dentistry -UEL/PR with the objective of promoting dental care for children in situation of social vulnerability assisted by the institution Casa Acolhedora Mãe e Senhora de Todos os Povos-Londrina-PR. The students promoted cultural and educational actions with 85 children and their families, including dental care, oral hygiene instruction and supply of oral hygiene materials. Workshops were organized addressing oral health, pregnancy and sexually transmitted diseases, diet, smoking and dental trauma. The students developed educational and cultural activities, such as the Solidarity campaign at the beginning of the school semester and celebration of festive dates with the purpose of drawing attention to health lifestyle and collecting school material and toys. The integration of undergraduate and graduate students with the community allowed the training of professionals in prevention and raised awareness of their role in addressing social demands. It was also possible to identify that it is necessary to extend dental care to parents, due to the progress of children's and adolescents' treatments.

Context Escitalopram (ESC) use during pregnancy has not been associated with teratogenic effects in fetuses. Aims To investigate whether ESC administered during pregnancy in mice induces maternal toxicity and teratogenicity in offspring. Methods Treated mice groups G1 and control G0 (n = 15 per group). Administration of ESC (G1) and saline solution (G0) during pregnancy and euthanasia on the 18th day. Pregnant female mice were treated with ESC (20 mg/kg, via gavage) or saline solution (control group) from the 5th to the 17th day of gestation, when implantation was consolidated. During intraembryonic development until the day before delivery, the drug had an influence on the development of alterations from its maintenance in the uterine environment and its development to the disturbance causing skeletal or visceral malformations. Key results The intrauterine development parameters that were altered by ESC treatment were: number of resorptions (G0: [0.93 ± 0.24]); G1: [3.33 ± 0.51]), post-implantation loss (G0: [3.95 ± 1.34], G1: [13.75 ± 3.62]) and reduced fetal viability: [97.30 ± 1.00]; G1: [81.09 ± 6.22]). Regarding fetal formation, the treated group had visceral malformations with a significant frequency: cleft palate (G0: [1.0%], G1: [11.86%]) and reduced kidneys (G0: [0%]; G1: [10.17%]). Regarding skeletal malformations, a higher frequency was observed in the following parameters: incomplete supraoccipital ossification (G0: [0%], G1: [15.25]), absence of ribs (G0: [0%], G1 (G0: [0%], G1 [15.25%]) and absence of one or more of the foot phalanges (G0: [1.0%]; 64%]). Conclusion Results indicate that ESC is an embryotoxic and teratogenic drug. Implications Until further studies are performed, greater caution is necessary in prescribing the drug to pregnant women.

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Physiological alterations in pregnancy may induce changes in salivary secretion and a predisposition to anxiety disorders. Clonazepam, a benzodiazepine, is recommended as the first choice for the treatment of anxiety disorders. To date, no studies have described the consequences of using this drug on the salivary glands of pregnant women. Therefore, the objective was to evaluate the alterations induced by exposure to Clonazepam in the salivary glands of pregnant mice. Twenty-two pregnant Swiss mice were divided into a control group (C) and a treated group (T), which received distilled water and 10 mg Kg-1 of Clonazepam, respectively, via gavage, daily, from the 5 to the 17th day of pregnancy. On the 18th day, euthanasia and collection of salivary glands were carried out, and the salivary glands were histologically processed and morphometrically analyzed under an optical microscope. The area, perimeter, and diameter of the acini and the thickness of the secretory ducts of each gland were measured. Parametric data (expressed as mean and standard deviation) were analyzed using the Student's t-test, and non-parametric data (expressed as median and interquartile range) using the Mann-Whitney test (p <0.05). Parotid glands’ acinar diameters (C: 44.1 ± 12.2 µm; T: 36.5 ± 7.8 µm; p =0.002) and ductal thicknesses (C: 16.9 [14.3-21.3] µm; T: 15.1 [13.4-16.3] µm; p =0.043) were statistically smaller in the T group than in the C group. No further alterations were found in other parameters from parotid glands, nor in submandibular and sublingual glands. It is concluded that Clonazepam induces morphological alterations in the parotid glands of pregnant mice. These alterations are probably associated with hyposalivation and xerostomia, already described as a common complaint among the users of benzodiazepines. Further studies are, therefore, suggested to assess the implications of these findings on pregnant women’s oral health.