A 10-year-old, spayed female, mixed-breed dog was referred for evaluation of bilateral hindlimb edema and weakness. Abdominal ultrasonography showed increased echogenicity of the lumen of the caudal vena cava from the level of the urinary bladder to the level of the cranial pole of the right kidney. Bilateral saphenous venograms displayed numerous filling defects in the caudal vena cava, right external iliac vein, right femoral vein, and the right common iliac vein. Extensive venous thrombosis was diagnosed, and the animal was euthanized. Necropsy confirmed the presence of venous thrombosis and revealed a right adrenocortical carcinoma that had invaded the caudal vena cava.

Mild to marked splenomegaly was observed in three of four rheas that died acutely in three unrelated commercial ratite facilities in Southeastern Louisiana. Mortalities occurred within a 5-week period in birds ranging from 2 months to 3 years of age. Multifocal hepatic and splenic necrosis with mononuclear cell infiltrates, typical of chlamydiosis in other avian species, was present on histopathologic sections. The diagnoses were confirmed by demonstration of inclusion bodies in splenic impression smears and fluorescent-antibody testing performed on Vero cell cultures.