Background: Irreparable rotator cuff tears lead to superior translation of the humeral head. Numerous surgical management options are available to treat the condition. Purpose: To compare superior capsule stability among different types of patch grafting in irreparable rotator cuff tears. Methods: Six cadaveric shoulders were tested in a custom-designed shoulder testing system. Superior translation of the humerus and subacromial contact pressure were quantified in an intact condition (condition 1), after cutting the supraspinatus tendon (condition 2), and after additionally cutting the superior capsuloligamentous complex (condition 3). The results were compared among 3 types of patch grafting, in which capsule reconstruction was achieved by glenoidal 3-point (condition 4) or 2-point (condition 5) fixation or by affixing a graft below the acromion (condition 6). Results: No significant difference in subacromial pressure was measured by reconstruction with 2 or 3 anchors compared with conditions 1 and 2 ( P > .05). However, with 3-point fixation, lower levels of pressure were measured than with 2-point fixation. Moreover, superior translation values were lower with 3-point fixation; the same applied for values of the preserved capsule as compared with the torn capsule. In condition 6, a significant increase in pressure in the neutral position was documented ( P < .05). Conclusion: The superior capsuloligamentous complex plays an important role in stabilizing the glenohumeral joint. The results suggest that with additional medial anchoring at the coracoid base, the depressing and centering effect of the superior complex can probably be regained in a more physiological way compared with a reconstructed capsule with 2 glenoid attachments or with an interpositional graft below the acromion.

Cancer can be identified as an uncontrolled growth and reproduction of cell. Accumulation of genetic aberrations (mutations of oncogenes and tumor-suppressor genes and epigenetic modifications) is one of the characteristics of cancer cell. Increasing number of studies highlighted importance of the epigenetic alterations in cancer treatment and prognosis. Now, cancer epigenetics have a huge importance for developing novel biomarkers and therapeutic target for cancer. In this review, we will provide a summary of the major epigenetic changes involved in cancer and preclinical results of epigenetic therapeutics.

Pale Liverwort-Chiloscyphus polyanthos is one of the most common aquatic liverworts that growing in or near the watering streams and lakes. It typically formed extensive matting appearance in the water or on the boulders in the water. In this study, Chiloscyphus polyanthos collected from the Erciyes Mountain were extracted using ethyl acetate, methanol, and water-methanol solvents. Cytotoxic and genotoxic effects of extracts against human peripheral blood lymphocytes were investigated. The genotoxic activity was determined by using the Chromosome Aberration Test. The cytotoxic activities of the extracts were determined by the Mitotic index (MI). The results showed that the extracts had cytotoxic effect and not genotoxic effect. According to this result, we estimate that Chiloscyphus polyanthos can be used as medicinal plant.

Miyokard hasarını belirlemekte kardiyak troponin tetkikinin özgüllüğü yüksektir. Troponin düzeyi yüksekliği hem kardiyak hem de kalp dışı nedenlerle gelişebilir. Bu çalışmada, kardiyak troponin istenen hastaların demografik özellikleri, başvuru yakınmaları ve tetkik sonuçlarının değerlendirilmesi amaçlanmıştır.

Bu çalışma, Zonguldak il merkezinde yaşayan 0-5 yaş arası çocuklarda rotavirüs sıklığını, anne-babaların rotavirüse yönelik bilgi düzeylerini ve uygulamalarını belirlemek amacıyla yapılmıştır. Yöntem: Çalışma kesitsel tanımlayıcı tipte bir araştırmadır. Çalışma, Mart 2019-Mayıs 2019 tarihleri arasında 354 anne-baba ile gerçekleştirilmiştir. Verilerin değerlendirilmesinde aritmetik ortalama, standart sapma, ortanca, minimum-maximum, yüzde-sayı değerleri ve ki kare testi kullanılmıştır. Bulgular: Çalışmada, anne babaların %15.5'i çocuklarının rotavirüs ile karşılaştığını ifade etmiştir. Anne-babaların %57.6'sının rotavirüs enfeksiyonunu, %51.1'inin rotavirüs aşısını bildiği belirlenmiştir. Ailelerin rotavirüs aşısı yaptırmama nedenleri arasında aşıyı duymama ve maddi olanaksızlıklar yer almaktadır. Sonuç: Çalışmada, anne-babaların rotavirüs aşısını bilme oranının yüksek olmasına rağmen, rotavirüs aşısı yaptırma oranının düşük olduğu tespit edilmiştir. Annelerin eğitim düzeyi arttıkça rotavirüs aşısını yaptırma oranlarının arttığı belirlenmiştir.