A subtype of PD with functional neurological features is familial in one-fourth of cases and associated with more psychiatric than motor disability and greater use of diagnostic and healthcare resources than those without functional features. Functional manifestations may be prodromal to PD in one-third of patients.

Academic calendars and university timelines set an urgent pace for researchers, which can hinder the establishment of long-term community partnerships. Given community-based participatory research’s (CBPR) emphasis on community-led research, time constraints can inhibit academic researchers’ commitments to collaborative methodologies and participatory research. This article considers how CBPR can be adapted for shorter-term engagements while still producing mutually beneficial research. In doing so, we contribute to the existing corpus on rapid assessment methodologies, characterized for adopting methods traditionally practiced over a longer duration to shorter time frames. We review the successes and limitations of a CBPR project executed within the timespan of six months in Flint, Michigan. In the case discussed, photo-voice enabled the inclusion of diverse ways of knowing, horizontal partnerships, reciprocal learning, and an accessible disemmination format within a CBPR framework. In conclusion we assert that there is value in short-term CBPR, especially for emergent issues where there is a need for rapid, responsive methodologies. However, short-term CBPR is a sprint, rather than a marathon; although shorter in duration, it is more intensive. It requires significant methodological commitments, flexibility, and an intensified workload for those involved.

SRX246 is a vasopressin (AVP) 1a receptor antagonist that crosses the blood-brain barrier. It reduced impulsive aggression, fear, depression and anxiety in animal models, blocked the actions of intranasal AVP on aggression/fear circuits in an experimental medicine fMRI study and demonstrated excellent safety in Phase 1 multiple-ascending dose clinical trials. The present study was a 3-arm, multicenter, randomized, placebo-controlled, double-blind, 12-week, dose escalation study of SRX246 in early symptomatic Huntington’s disease (HD) patients with irritability. Our goal was to determine whether SRX246 was safe and well tolerated in these HD patients given its potential use for the treatment of problematic neuropsychiatric symptoms. Participants were randomized to receive placebo or to escalate to 120 mg twice daily or 160 mg twice daily doses of SRX246. Assessments included standard safety tests, the Unified Huntington’s Disease Rating Scale (UHDRS), and exploratory measures of problem behaviors. The groups had comparable demographics, features of HD and baseline irritability. Eighty-two out of 106 subjects randomized completed the trial on their assigned dose of drug. One-sided exact-method confidence interval tests were used to reject the null hypothesis of inferior tolerability or safety for each dose group vs. placebo. Apathy and suicidality were not affected by SRX246. Most adverse events in the active arms were considered unlikely to be related to SRX246. The compound was safe and well tolerated in HD patients and can be moved forward as a candidate to treat irritability and aggression.

Household water insecurity is a global problem; one not escaped by residents of high-income nations. In this article, we review a community-based participatory research (CBPR) project conducted in Flint, MI, to document grassroots narratives about the impacts of water insecurity on the lives of women. In 2014, Flint residents found themselves connected to modern water infrastructure that delivered potable water contaminated by lead and pathogens. Through a photovoice method, participating women documented how experiences of water insecurity continues to impact their lives many years after state authorities declared the water crisis to be over. This study adds to a growing literature that highlights how the “adequateness” of water quality is not a stable or self-evident condition for there are different frameworks for water cleanliness, safety, and risk. With attention to methodology, this case study emphasizes the importance of legitimizing the embodied experience of participants through research design and implementation. This CBPR project contributes to the existing toolbox of methods for studying household water insecurity by complementing the growing literature on security metrics with a narrative-focused approach to documenting women’s lived experiences of water insecurity. Finally, the article invites readers to consider how and to what degree to mobilize participatory approaches to understand conditions and lived experiences of resource insecurity without further stigmatizing or exploiting impacted communities.

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