Swiss Webster female mice weighing 25-30 gm were injected subcutaneously on days 6-15 of gestation with the synthetic sex steroid Delalutin (17 alpha-hydroxyprogesterone caproate). Treatment was given daily in doses ranging from 42 to 833 mg/kg body weight, or 10, 100, and 200 times the human therapeutic dose. On day 18 fetuses were removed from the uterus and examined for malformations and other fetotoxic effects. Prenatal treatment with the two higher doses resulted in 8 and 13% maternal deaths, and all doses resulted in a slight increase (4-12% above control) in resorption frequency. Treatment with Delalutin did not significantly affect intrauterine growth, sex ratio, or malformation rate of the offspring. The results of the present study confirm other reports that Delalutin is not androgenic, and that it, like progesterone and certain other sex steroids, does not alter the development of nonreproductive organs.
Efficient access to multiple permeable natural gas zones located in deep, over pressured, and extremely corrosive environments presents a challenge for South Texas operating companies. An innovative completion technique, featuring corrosion resistant alloy (CRA) tubulars has been effectively implemented by blending features of monobore, slim-hole, and conventional completion geometries. Introduction After attempting to produce deep, hot, corrosive, high-pressure Wilcox gas in Duval County, Texas efficiently, operators were faced with engineering and economic challenges. One operator decided to rethink the entire well planning process and asked, "What's important to produce these wells in the most economic and safe manner?" Casing cementing success, high rate stimulation, and high production capacity in a corrosive environment are the ingredients that must be blended into a successful well. High rate production (+/–30 MMcf/D) and the need for high rate (30 to 35 bbl/min) fracture stimulation, due to 50 to 300 ft thick reservoirs, dictated the use of 3 1/2-in. production tubing or larger. Operators face a number of challenges as they attempt to produce natural gas from the deep Wilcox formations of South Texas. A successful prospect can yield 15 to 30 MMcf/D making the rewards substantial. However, the increased costs of CRA tubulars jeopardize the economics of a project if these rates are not achieved. As a consequence, drilling and completion technology is routinely tested before the rewards can be realized. Chief among the problems to overcome are environmental conditions encountered at the producing interval and at total depth (TD). Hurdles that stand between the operator and completion of a profitable well include:Temperature - The South Texas thermal gradient is among the steepest in the world. Temperature changes in excess of 2°F per 100 ft of well depth are common throughout the area. Bottomhole temperatures of 420°F at depths as shallow as 17,000 ft contribute to chemical inhibition, material selection, and yield strength derating problems.Pressure - Not only is the temperature gradient abnormally steep, but so is the pressure advancement with well depth. An 18.0-ppg mud at 17,000 ft is required to drill the deeper Wilcox formation wells.Acid Gas - South Texas gas composition varies greatly across the region. Many of the wells carry some component of both hydrogen sulfide (H2S) and carbon dioxide (CO2). The wells targeted by this study are "mildly" sour, 30 to 60 ppm, or approximately 1 psi partial pressure H2S and produce 11 to 12% CO2, approximately 1,900 psi partial pressure.Chlorides - Chlorides in produced water range from 30,000 to 100,000 ppm, which is high enough to affect material selection. Combined with several hundred barrels of formation water produced per day, the production flowstream can be termed extremely corrosive.Cost - A difficult economic consideration of the Wilcox trend is that while individual wells may have high rates of return, total project economics may often be much lower. As a consequence, the success or demise of any well is dependent on the relative cost of the hydrocarbon producing installation. Maximum income or revenue from deep, hot South Texas wells is naturally fixed by the producing formations. Significant reduction in cost directly increases the profit margin. Initial cost must be weighed against risk in order to fully appreciate value. No completed well or field economics are addressed herein, but a summary of direct costs and associated risks is explored further in the body of this technical treatise. The optimum answer to deep, hot, sour gas production in South Texas is to provide a corrosion resistant conduit for high volumes of gas and to make it equal to or cheaper than a conventional well. Safety compromises are not allowed.
The conference will be held a t the Hilton Hotel in Salt Lake City, Utah and January 7-9, 1996 and will feature application of reproductive technologies in wild, exotic or endangered species, application of reproductive technologies in domestic animals, cellular aspects of embryogenesis, defined culture media, application of transgenesis to 1ivestocWembryo development? and activation of the oocyte and in vitro embryo production and manipulation. There will also be a post-conference symposium that will include topics in the areas of comparative vertebrate embryogenesis, blastomere differentiation and cell lineage, microanatomy during early cleavage, gene expression during embryogenesis, molecular basis of cellular communication, and the role of cell adhesion proteins in embryogenesis.Abstract instructions as well as information about the student competition and travel awards may be obtained from:
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
customersupport@researchsolutions.com
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.