Since the isolation of tyrothricin from cultures of Bacillus brevis (Dubos, 1939), numerous papers have appeared dealing with the chemical and biological properties of this bactericidal agent and its components, gramicidin and tyrocidine

ANTIMICROBIAL ACTION two limbs and followed by death. A small number of paralyzed hamsters survived, but developed atrophy and contractures of the affected muscles. The pathology in the infected hamsters is typical of poliomyelitis. The hamster strain is infectious for mice. Human convalescent poliomyelitis serum neutralized the hamster strain. Hamster convalescent serum neutralized the hamster OF ANTIBIOTIC AGENTS strain as well as the mouse strain. The hamster strain inoculated intracerebrally into 4 monkeys produced no paralysis. Three monkeys, subsequently tested with virulent monkey cord virus, proved to be immune.

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