Purpose: To evaluate the visual outcome after direct laser photocoagulation of the worm in patients with early-stage diffuse unilateral subacute neuroretinitis (DUSN). Methods: We report on four patients with DUSN diagnosed in its early stage, in whom the worm was identified and destroyed by laser photocoagulation. Results: In all the four cases, resolution of the inflammatory multifocal lesions was achieved within 1 month of treatment. After that period and during follow-up (mean 11.5 months), visual acuity improved in three eyes and remained unchanged in one eye. Conclusion: The diagnosis of DUSN in its early stage followed by prompt location and destruction of the worm by photocoagulation may improve vision of affected patients.
The prevalence of systemic toxoplasmosis, although high, was lower than that found in studies performed in the South and Southeast of Brazil, and the incidence of ocular lesions was totally different, being lower by a factor varying from 5 to 17. Although important epidemiological variables, such as owning a cat, drinking unfiltered water or having had contact with lakes or rivers, were found to be correlated with toxoplasmosis in the preliminary analysis, they lost their influence when included in the logistic model. However, further studies must be undertaken to identify the reasons for these findings, including the determination of the strains of Toxoplasma gondii encountered in different regions of the country and the sources of the water utilized by these populations.
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