At least 30-35% of men with erectile dysfunction (ED) fail to respond to treatment with phosphodiesterase type 5 (PDE-5) inhibitors. Testosterone (T) has effects not only on sexual desire, but also on the anatomical and physiological substrate of erection. This study analysed the effects of T administration to men unsuccessfully treated for ED with PDE-5 inhibitors only. Twenty-nine men aged 36-75 years (mean 59 years) with ED were studied. They suffered from ED for a mean of 2.7 years and had subnormal plasma T levels (total T <3.5 ng ml(-1) ). They received parenteral testosterone undecanoate for 102 weeks. Changes of the domains of the International Index of Erectile Function (IIEF) were assessed. After 6 weeks of T treatment, the sexual desire domain of IIEF had improved (from 4.1 ± 1.4 to 7.2 ± 1.7) and erectile function as measured by IIEF started to improve, reaching a plateau after 30 weeks (from 9.1 ± 2.1 to 26.5 ± 2.3). Features of the metabolic syndrome also improved. There were no adverse effects of T administration. Addition of T to treatment of hypogonadal men unsuccessfully treated with PDE-5 inhibitors only, appeared useful and acceptably safe.

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Patients with resection of PM of CRC with history of resected hepatic metastases presented significantly lower disease specific survival rates than those undergoing pulmonary metastasectomy alone. CEA before lung surgery and bilateral PM associated worse prognosis.

INTRODUCCIÓNLa menopausia, etapa fisiológica de la vida de la mujer, se caracteriza por cambios significativos a nivel orgánico, psicológico y social, debido a modificaciones en la función endocrina, con disminución de los niveles circulantes de estrógenos, que dan lugar a alteraciones a nivel de la composición corporal, con el aumento del tejido adiposo y del peso corporal y modificaciones en la distribución de grasa, debido a la marcada influencia de estas hormonas sobre este tejido (1,2).Entre los indicadores antropométricos que evalúan estos cambios , se encuentran el índice de masa corporal (IMC), que permite categorizar el estado nutricional y diagnosticar estados de malnutrición por exceso como el (1) Instituto de Investigaciones en Nutrición (INVESNUT). Facultad de Ciencias de la Salud. Universidad de Carabobo. Valencia, Venezuela.(2) Escuela de Medicina. Facultad de Ciencias de la Salud. Universidad de Carabobo. Valencia, Venezuela.sobrepeso y la obesidad, los cuales alcanzan frecuencias altas en las mujeres posmenopáusicas evaluadas (3). La circunferencia de cintura (CCi), mide indirectamente la acumulación de grasa abdominal, y ha sido sugerida como un predictor de riesgo para las enfermedades cardiovasculares y metabólicas. Este indicador se ve afectado por los cambios en la distribución de la grasa corporal, observado en la posmenopausia (3-5).La disminución de los estrógenos en la mujer posmenopáusica no sólo contribuye a la existencia de alteraciones a nivel de la composición corporal, sino también a la elevación de los valores de homocisteína. Este, es un amino ácido azufrado producido intercelularmente por la desmetilación de la metionina. Evidencias epide-ABSTRACT Menopause is associated with an increased body weight and changes in fat distribution, high levels of homocysteine and cardiovascular risk factors associated with estrogen deficiency. The objective was to evaluate body mass index (BMI), waist circumference (WC), waist/hip index (WHI), and serum homocysteine (Hct) levels in postmenopausal women (n 128). Nutritional status was diagnosed by BMI (WHO), WC (normal <88cm, at risk> 88cm), WHI (normal <0.8, at risk> 0.8), serum homocysteine (Hct) (ELISA) normal < 10 mmol/L, at risk >10-15mmol/L, high >15mmol/L and estradiol (ELISA) <65pg/mL (menopause). Sixty five point nine % were overweight/obese, 47.3% and 82.2% showed cardio metabolic risk by WC and WHI. There was a significant difference for WHI, and a positive significant correlation between anthropometrics indexes. Ten % showed risk and hyperhomocysteinaemia, but it was not correlated with the evaluated variables. The subjects had a high frequency of overweight, obesity and android fat distribution, showing a high risk for cardiometabolics diseases.

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