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At the end of the year of 1895, Wilhelm Roentgen presented to the medical community his X-rays discovery. The first notice that came to the Mexico National School of Medicine arrived through a letter coming from the Office of Justice and Public Instruction written by the Secretary of Foreign Relations. Fulfilling the Porfirio Diaz Government instructions to update the medical knowledge. The aim of this paper is to present an historical review of primary sources to document how and who were the prominent figures who introduce this new knowledge at the Mexico National School of Medicine, and how it gets inside study plans, more specific into Physics and Natural History, and its application in the Hospitals. In Mexico City the outlined names are doctor Carmona y Valle, Tobías Núñez, Roberto Jofre, Secundino Sosa and Amador Zafra with the first thesis on X-rays.

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