Pregnant women who have COVID-19 have an increased risk of hospitalization and death; however, there are many restrictions for the application of COVID-19 vaccines on pregnant patients, mainly because there is no confirmation of the safety of their use during pregnancy. None of the vaccines approved to date are based on live attenuated SARS-CoV-2, so the possibility of generating an infection in the fetus is nonexistent.

The relationship of COVID-19 and pregnancy implies a novel clinical condition, information regarding the true medical picture is currently being collected. The present work aims to carry out a review of the most prominent publications on COVID-19 and Pregnancy: epidemiology and clinical evolution based on currently available evidence.

The fetus and placenta are an immunologically privileged unit, whose physiological changes during pregnancy intervenes in the behavior against SARS-CoV- 2, describing a theoretical potential teratogenic damage due to receptors ACE-2 expression, necessary for SARS-CoV-2 intracellular transport in the epiblast, vital in organogenesis, as well as the current pharmacological therapy teratogenic effects, abortions, and fetal demise.