The development of new classes of dental materials determined the apparition of reinforced polymers, as BioHPP and Trinia, used for core in non-metallic prosthetic restorations, including in implants non-metallic superstructure. The purpose of the study was to present the results of the comparative clinical trials referring to the use of BioHPP and Trinia resins as core in fixed prosthetic rehabilitation. The researches were performed on 33 patients in which we realized 71 fixed prosthetic restorations. According to the six evaluation criteria used in research, we conducted biannual monitoring meetings over two and half years period for registrations of comparative results in the use of these two reinforced polymers as core. The results of the study demonstrated that both type of these materials exhibit a certain degree of elasticity and presents many advantages, therefore these represent a beneficial acquisition in patients oral health.

The intraosseous implants are the most used dental implants. The development of new classes of dental biomaterials determined the apparition of Trinia, a Computer-Aided Design/Computer-Aided Manufacturing (CAD/CAM) reinforced polymer, used for core in non-metallic prosthetic restorations, including implants superstructure. The aim of the study was to present the obtained results in the use of Trinia polymer as non-metallic core on the abutments of Bicon implants. 35 patients were selected, 19 females and 16 males, aged between 31 and 60 years. After 18 months of results monitoring, we ascertained that Trinia reinforced polymer had a very good behavior in the oral cavity, and the patients did not complain about inconveniences due to the oral rehabilitation with this biopolymer.

The present study aimed to investigate the link between the severity of periodontal disease (PD), coronary calcifications and unstable plaque features in patients who underwent coronary computed tomography for unstable angina (UA). Fifty-two patients with UA, included in the ATHERODENT trial (NCT03395041), underwent computed tomographic coronary angiography (CCTA) and dental examination. Based on the median value of the periodontal index (PI), patients were assigned to the low periodontal index (LPI) group (PI < 22) and a high periodontal index (HPI) group (PI > 22). Patients with HPI had higher plaque volume (p = 0.013) and noncalcified plaque volume (p = 0.0003) at CCTA. In addition, the presence of vulnerability features in the atheromatous plaques was significantly correlated with PI (p = 0.001). Among periodontal indices, loss of gingival attachment (p = 0.009) and papillary bleeding index (p = 0.002) were strongly associated with high-risk plaques. PI significantly correlated with coronary calcium score (r = 0.45, p = 0.0008), but not with traditional markers of subclinical atherosclerosis. Overall, this subgroup analysis of the ATHERODENT study indicates that patients with advanced PD and UA present a higher amount of calcium in the coronary tree and have a more vulnerable phenotype of their culprit plaques.

Our objective was to investigate immunological changes that occur in saliva of subjects with type 2 diabetes mellitus (T2DM) without signs of periodontal disease and to establish if salivary inflammatory cytokines are a possible link between diabetes mellitus and periodontal breakdown.Material and methods. Twenty T2DM subjects with no periodontal disease and twenty healthy controls were registered for the present study. TNF-α and IL-6 level from saliva and serum were measured. Periodontal tissue samples were histologically examined.Results: TNF-α and IL-6 levels were higher in T2DM subjects compared to controls, with an extremely significant difference in saliva (p<0.001). Significant inflammation, affecting both epithelial and connective tissues was present in periodontal biopsies.Conclusions: The subjects showed an increased TNF-α and IL-6 levels, both in serum and -mostly in -saliva of diabetics without signs of periodontal disease, confirming the hypothesis of immunological implication, as a correlation between periodontal disease incidence and diabetes mellitus. Histologic alterations, suggesting a local inflammatory state, were present in periodontal tissue of diabetics, confirming the above hypothesis. The study reveals that saliva analysis is a quite efficient method in testing the periodontal breakdown progression in the subjects with T2DM.

The high frequency of occurrence of candidiasis as well as high mortality of patients with immunosuppression cause a tendency toward better understanding of Candida albicans species virulence factors and developing sensitive and specific diagnostic methods, and appropriate strategies of candidiasis treatment. In recent decades the incidence of fungal infections has alarming increases because of advanced medical treatments. In this study was analyzed possible ultrastructural changes of the species C. albicans cells following treatment with sodium diclofenac at various concentrations. Following treatment of C. albicans cells with sodium diclofenac 1 mM and 2 mM changes in the plasmalemma can be noticed, changes in the density of cell wall, disruption and necrotic appearance of the cytoplasm.